Targeting the SARS-CoV-2 RNA Genome with Small Molecule Binders and Ribonuclease Targeting Chimera (RIBOTAC) Degraders

Hafeez S. Haniff, Yuquan Tong, Xiaohui Liu, +8

ACS Central Science

Bacterial-derived exopolysaccharides enhance antifungal drug tolerance in a cross-kingdom oral biofilm

Dongyeop Kim, Yuan Liu, Raphael I. Benhamou, +7

The ISME Journal

Microbial PathogensBacterial-derived ExopolysaccharidesOral MicrobiologyAntimicrobial ChemotherapyDrug Resistance +16

Programming inactive RNA-binding small molecules into bioactive degraders

Yuquan Tong, Yeongju Lee, Xiaohui Liu, +22

Nature

Reprogramming of Protein-Targeted Small-Molecule Medicines to RNA by Ribonuclease Recruitment

Peiyuan Zhang, Xiaohui Liu, Daniel Abegg, +11

Journal of the American Chemical Society

Ribonuclease RecruitmentCanonical TargetEngineeringDrug TargetMolecular Biology +17

Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(G ₄ C ₂ ) repeat expansion in vitro and in vivo ALS models

Jessica A. Bush, Haruo Aikawa, Rita Fuerst, +21

Science Translational Medicine

Real-Time Imaging of the Azole Class of Antifungal Drugs in Live Candida Cells

Raphael I. Benhamou, Maayan Bibi, Kfir B. Steinbuch, +5

ACS Chemical Biology

Live Candida CellsEngineeringFungal Cell BiologyMicroscopyMolecular Biology +20

Antifungal activity, mode of action variability, and subcellular distribution of coumarin-based antifungal azoles

Rebecca Elias, Raphael I. Benhamou, Qais Z. Jaber, +5

European Journal of Medicinal Chemistry

Antifungal AgentAntifungal ActivityAntifungal AgentsMedicineAction Variability +4

Structural insights of lincosamides targeting the ribosome of Staphylococcus aureus

Donna Matzov, Zohar Eyal, Raphael I. Benhamou, +8

Nucleic Acids Research

Bioorganic ChemistryMolecular BiologyAntimicrobial ChemotherapyChemical BiologyPharmaceutical Chemistry +17

DNA-encoded library versus RNA-encoded library selection enables design of an oncogenic noncoding RNA inhibitor

Raphael I. Benhamou, Blessy M. Suresh, Yuquan Tong, +8

Proceedings of the National Academy of Sciences

A Small Molecule that Binds an RNA Repeat Expansion Stimulates Its Decay via the Exosome Complex

Alicia J. Angelbello, Raphael I. Benhamou, Suzanne G. Rzuczek, +9

Cell chemical biology

Rna Repeat ExpansionNatural SciencesRna Binding ProteinsRna Structure PredictionRna Biology +9