Crystal structure of the sodium–potassium pump

Jens Preben Morth, Bjørn Panyella Pedersen, Mads S. Toustrup-Jensen, +5

Nature

Crystal StructureCrystallographyCrystal Structure DesignBiophysics

Somatic mutations in ATP1A1 and ATP2B3 lead to aldosterone-producing adenomas and secondary hypertension

Felix Beuschlein, Sheerazed Boulkroun, Thomas Wieland, +26

Nature Genetics

HypertensionSomatic MutationsGeneticsPhysiologySecondary Hypertension +6

Crystal structure of a Na+-bound Na+,K+-ATPase preceding the E1P state

R. Kanai, Haruo Ogawa, Bente Vilsen, +2

Nature

Crystal StructureBiochemistryBiophysicsNatural SciencesProtein X-ray Crystallography +6

Somatic <i>ATP1A1</i> , <i>ATP2B3</i> , and <i>KCNJ5</i> Mutations in Aldosterone-Producing Adenomas

Tracy Ann Williams, Silvia Monticone, Vivien R. Schack, +17

Hypertension

Molecular PharmacologyMolecular PhysiologySomatic MutationsBiochemistryAldo-keto Reductase +13

Functional Consequences of Proline Mutations in the Cytoplasmic and Transmembrane Sectors of the Ca2+-ATPase of Sarcoplasmic Reticulum

Bente Vilsen, Jens Peter Andersen, David M. Clarke, +1

Journal of Biological Chemistry

Site-specific MutagenesisMolecular BiologyCellular PhysiologyFunctional ConsequencesStructure-function Enzyme Kinetics +16

Mutation I810N in the α3 isoform of Na ⁺ ,K ⁺ -ATPase causes impairments in the sodium pump and hyperexcitability in the CNS

Steven J. Clapcote, Steven Duffy, Gang Xie, +14

Proceedings of the National Academy of Sciences

Sodium PumpSynaptic TransmissionMolecular BiologySynaptic SignalingCellular Physiology +25

Mania-like behavior induced by genetic dysfunction of the neuron-specific Na ⁺ ,K ⁺ -ATPase α3 sodium pump

Greer S. Kirshenbaum, Steven J. Clapcote, Steven Duffy, +10

Proceedings of the National Academy of Sciences

Synaptic TransmissionNeurotransmissionSynaptic SignalingSocial SciencesNeurochemistry +21

Dissection of the Functional Differences between Sarco(endo)plasmic Reticulum Ca2+-ATPase (SERCA) 1 and 2 Isoforms and Characterization of Darier Disease (SERCA2) Mutants by Steady-state and Transient Kinetic Analyses

Leonard Dode, Jens Peter Andersen, Natalie Leslie, +3

Journal of Biological Chemistry

Functional Consequences of Mutations in the β-Strand Sector of the Ca2+-ATPase of Sarcoplasmic Reticulum

Jens Peter Andersen, Bente Vilsen, Ekkehard Leberer, +1

Journal of Biological Chemistry

Critical roles of isoleucine-364 and adjacent residues in a hydrophobic gate control of phospholipid transport by the mammalian P4-ATPase ATP8A2

Anna L. Vestergaard, Jonathan A. Coleman, Thomas Lemmin, +6

Proceedings of the National Academy of Sciences