The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation

Takaomi Okawa, Carmen Z. Michaylira, Jiří Kalabis, +9

Genes & Development

Esophageal CancerP53 MutationPathologyHtert ActivationEpithelial-mesenchymal Interactions +12

A subpopulation of mouse esophageal basal cells has properties of stem cells with the capacity for self-renewal and lineage specification

Jiří Kalabis, Kenji Oyama, Takaomi Okawa, +8

Journal of Clinical Investigation

Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage

Masahiko Kobayashi, Yoshio Naomoto, Tetsuji Nobuhisa, +11

Differentiation

Developmental BiologyEsophageal Keratinocyte DifferentiationHeparan Sulfate CleavageNatural SciencesMolecular Biology +5

Colonic interposition and supercharge for esophageal reconstruction

Yasuhiro Shirakawa, Yoshio Naomoto, Kazuhiro Noma, +13

Langenbeck s Archives of Surgery

EsophagusGastroenterologyThoracic SurgeryColonic InterpositionSurgery +3

Translocation of heparanase into nucleus results in cell differentiation

Tetsuji Nobuhisa, Yoshio Naomoto, Takaomi Okawa, +15

Cancer Science

AKT induces senescence in primary esophageal epithelial cells but is permissive for differentiation as revealed in organotypic culture

Kenji Oyama, Takaomi Okawa, Hiroshi Nakagawa, +8

Oncogene

InflammationOrganotypic CultureDevelopmental BiologyCell RegulationApoptosis +8

Heparanase Is Involved in Angiogenesis in Esophageal Cancer through Induction of Cyclooxygenase-2

Takaomi Okawa, Yoshio Naomoto, Tetsuji Nobuhisa, +9

Clinical Cancer Research

Coordinated Functions of E-Cadherin and Transforming Growth Factor β Receptor II <i>In vitro</i> and <i>In vivo</i>

Claudia D. Andl, Brenton B. Fargnoli, Takaomi Okawa, +7

Cancer Research

EGF-mediated regulation of IGFBP-3 determines esophageal epithelial cellular response to IGF-I

Munenori Takaoka, Caitlin E. Smith, Michael K. Mashiba, +4

American Journal of Physiology-Gastrointestinal and Liver Physiology

Esophageal CancerImmunologyCell ProliferationTumor BiologySignaling Pathway +16

COX-2 induction by heparanase in the progression of breast cancer

Takako Imada, Junji Matsuoka, Tetsuji Nobuhisa, +12

International Journal of Molecular Medicine