J.A. Hutton

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus

Aurélie Mousnier, Andrew Bell, Dawid Swieboda et al. · Nature Chemistry · 2018 · 128 citations · Full text

Virus Structure, Viral Replication, Synthetic Virology +9

Structure-Based Design of Potent and Selective <i>Leishmania</i> <i>N</i>-Myristoyltransferase Inhibitors

J.A. Hutton, Victor Gonçalves, J.A. Brannigan et al. · Journal of Medicinal Chemistry · 2014 · 63 citations · Full text

Bioorganic Chemistry, Chemical Biology, Human Enzyme +17

Diverse modes of binding in structures of<i>Leishmania major</i><i>N</i>-myristoyltransferase with selective inhibitors

J.A. Brannigan, S.M. Roberts, Andrew Bell et al. · IUCrJ · 2014 · 43 citations · Full text

Drug Target, Molecular Biology, Selective Inhibitors +23

Architecture and hydration of the arginine‐binding site of neuropilin‐1

Filipa Mota, Constantina Fotinou, Rohini R. Rana et al. · FEBS Journal · 2018 · 37 citations · Full text

Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureus

Carine S.Q. Lim, Kam Pou Ha, Rebecca S. Clarke et al. · Bioorganic & Medicinal Chemistry · 2019 · 28 citations · Full text