Shi-Liang Tseng

Discovery of 2-[5-(4-Chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1<i>H</i>-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an Active Metabolite. A Novel, Potent and Selective Cannabinoid-1 Receptor Inverse Agonist with High Antiobesity Efficacy in DIO Mice

Chien-Huang Wu, Ming‐Shiu Hung, Jen‐Shin Song et al. · Journal of Medicinal Chemistry · 2009 · 42 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of 1-(2,4-Dichlorophenyl)-<i>N</i>-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1<i>H</i>-pyrazole-3-carboxamide as a Novel Peripherally Restricted Cannabinoid-1 Receptor Antagonist with Significant Weight-Loss Efficacy in Diet-Induced Obese Mice

Chun‐Ping Chang, Chien-Huang Wu, Jen‐Shin Song et al. · Journal of Medicinal Chemistry · 2013 · 36 citations

Pharmacy, Medicinal Chemistry, Pharmacology +13

Bioisosteric Replacement of the Pyrazole 5-Aryl Moiety of<i>N</i>-(Piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1<i>H</i>-pyrazole-3-carboxamide (SR141716A). A Novel Series of Alkynylthiophenes as Potent and Selective Cannabinoid-1 Receptor Antagonists

Shi-Liang Tseng, Ming‐Shiu Hung, Chun‐Ping Chang et al. · Journal of Medicinal Chemistry · 2008 · 26 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Biphasic suppression of appetite by cannabinoid CB1 receptor antagonists with distinct functional activities

Yinchiu Lin, Kak‐Shan Shia, Wen‐Chi Hsiao et al. · Pharmacological Research · 2010 · 11 citations

Medicine, Neuroscience, Pharmacology +12