Laurence Arnold

Phospho-dependent Regulation of SAMHD1 Oligomerisation Couples Catalysis and Restriction

Laurence Arnold, Harriet C. T. Groom, Simone Kunzelmann et al. · PLoS Pathogens · 2015 · 110 citations · Full text

Molecular Regulation, Molecular Biology, Samhd1 Activity +16

The Interface between Catalytic and Hemopexin Domains in Matrix Metalloproteinase-1 Conceals a Collagen Binding Exosite

Laurence Arnold, Louise E. Butt, Stephen H. Prior et al. · Journal of Biological Chemistry · 2011 · 55 citations · Full text

Matrix Metalloproteinase-1 Conceals, Protein Assembly, Molecular Biology +23

Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches

Patrick J. McIntyre, P.M. Collins, Lukáš Vrzal et al. · ACS Chemical Biology · 2017 · 54 citations

Molecular Biology, Tumor Biology, Mitotic Kinase Aurora-a +23

A Continuous Enzyme-Coupled Assay for Triphosphohydrolase Activity of HIV-1 Restriction Factor SAMHD1

Laurence Arnold, Simone Kunzelmann, Martin R. Webb et al. · Antimicrobial Agents and Chemotherapy · 2014 · 47 citations · Full text

Continuous Enzyme-coupled Assay, Antiviral Drug, Chemical Biology +17

Crystal structures of SAMHD1 inhibitor complexes reveal the mechanism of water-mediated dNTP hydrolysis

E.R. Morris, Sarah J. Caswell, Simone Kunzelmann et al. · Nature Communications · 2020 · 45 citations · Full text