Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid Leukemia

Yue Huang, Rui Su, Yue Sheng, +25

Cancer Cell

Hematological MalignancyBiochemistryNatural SciencesAcute Myeloid LeukemiaMixed-phenotype Acute Leukemia +6

Proteasome subunit Rpn13 is a novel ubiquitin receptor

Koraljka Husnjak, Suzanne Elsasser, Naixia Zhang, +6

Nature

Protein FunctionMolecular RegulationMedicineNatural SciencesProteasome +5

Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction

Patrick Schreiner, Xiang Chen, Koraljka Husnjak, +6

Nature

Molecular DockingProtein FunctionProtein AssemblyProtein FoldingMedicine +8

Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome

Yuan Shi, Xiang Chen, Suzanne Elsasser, +13

Science

Protein AssemblyProteasomeMolecular BiologyUbiquitin ChainSubstrate Binding +15

Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation

Jing Wang, Cheng Luo, Changliang Shan, +22

Nature Chemistry

Human Copper TraffickingCancer Cell ProliferationMedicineMetalloproteinBioactive Metal +8

Small-molecule targeting of a diapophytoene desaturase inhibits S. aureus virulence

Feifei Chen, Hongxia Di, Youxin Wang, +12

Nature Chemical Biology

Natural SciencesVirulence FactorMolecular BiologySelective ToxicitySmall-molecule Targeting +7

Structure of the S5a:K48-Linked Diubiquitin Complex and Its Interactions with Rpn13

Naixia Zhang, Qinghua Wang, Aaron Ehlinger, +8

Molecular Cell

Protein AssemblyBiochemistryNatural SciencesStructural BioinformaticsBiomolecular Structure Prediction +5

Fragment-Based Drug Discovery of 2-Thiazolidinones as Inhibitors of the Histone Reader BRD4 Bromodomain

Lele Zhao, Danyan Cao, Tiantian Chen, +13

Journal of Medicinal Chemistry

Molecular DockingFragment 8Medicinal ChemistryFragment-based Drug DiscoveryIntegrated Lead Optimization +12

Astemizole Arrests the Proliferation of Cancer Cells by Disrupting the EZH2-EED Interaction of Polycomb Repressive Complex 2

Xiangqian Kong, Limin Chen, Lianying Jiao, +14

Journal of Medicinal Chemistry

Sequence-based drug design as a concept in computational drug design

Lifan Chen, Zisheng Fan, Jie Chang, +21

Nature Communications

Drug TargetEngineeringMolecular BiologyMolecular DesignDrug Design +19