Alexandre Trottier

Discovery of a Non-Estrogenic Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 from 3-Substituted-16β-(<i>m</i>-carbamoylbenzyl)-estradiol Derivatives

René Maltais, Diana Ayán, Alexandre Trottier et al. · Journal of Medicinal Chemistry · 2013 · 31 citations · Full text

Pharmacokinetic profile of PBRM in rodents, a first selective covalent inhibitor of 17β-HSD1 for breast cancer and endometriosis treatments

René Maltais, Alexandre Trottier, Jenny Roy et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2017 · 18 citations

Pharmacokinetic Profile, Medicine, Hormonal Receptor +8

Impact of structural modifications at positions 13, 16 and 17 of 16β-(m-carbamoylbenzyl)-estradiol on 17β-hydroxysteroid dehydrogenase type 1 inhibition and estrogenic activity

René Maltais, Alexandre Trottier, Xavier Barbeau et al. · The Journal of Steroid Biochemistry and Molecular Biology · 2015 · 15 citations

Estrogenic Activity, Positions 13, Biochemistry +7

Insight into the mode of action and selectivity of PBRM, a covalent steroidal inhibitor of 17β-hydroxysteroid dehydrogenase type 1

Alexandre Trottier, René Maltais, Diana Ayán et al. · Biochemical Pharmacology · 2017 · 15 citations

Molecular Pharmacology, Medicinal Chemistry, Biochemistry +9

Identification of fused 16β,17β-oxazinone-estradiol derivatives as a new family of non-estrogenic 17β-hydroxysteroid dehydrogenase type 1 inhibitors

René Maltais, Alexandre Trottier, Audrey Delhomme et al. · European Journal of Medicinal Chemistry · 2015 · 12 citations · Full text

Molecular Pharmacology, Medicinal Chemistry, New Family +10