A Novel Small-Molecule Inhibitor of Mcl-1 Blocks Pancreatic Cancer Growth <i>In Vitro</i> and <i>In Vivo</i>

Fardokht A. Abulwerdi, Chenzhong Liao, Meilan Liu, +11

Molecular Cancer Therapeutics

Chemoprevention StrategyCancer BiologyTumor BiologyPancreatic CancerLead Compound 1 +16

PARP7 negatively regulates the type I interferon response in cancer cells and its inhibition triggers antitumor immunity

Joseph M. Gozgit, Melissa M. Vasbinder, Ryan Abo, +25

Cancer Cell

CytokineCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +7

3-Substituted-<i>N</i>-(4-Hydroxynaphthalen-1-yl)arylsulfonamides as a Novel Class of Selective Mcl-1 Inhibitors: Structure-Based Design, Synthesis, SAR, and Biological Evaluation

Fardokht A. Abulwerdi, Chenzhong Liao, Ahmed S.A. Mady, +6

Journal of Medicinal Chemistry

ImmunologyPharmaceutical ChemistryMolecular PharmacologyMedicinal ChemistryCompound 21 +17

Wnt/β-catenin signaling directs the regional expansion of first and second heart field-derived ventricular cardiomyocytes

Jan W. Buikema, Ahmed S.A. Mady, Nikhil Mittal, +5

Development

Cardiac MuscleCardiac Progenitor CellsNormal Cardiac DevelopmentCardiac RegenerationOrgan Development +25

The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics

William Giblin, Lauren Bringman-Rodenbarger, Angela H. Guo, +34

Journal of Clinical Investigation

ImmunologyEpigeneticsMelanoma CellsTumor BiologyMelanoma Viability +14

Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins

Karson J. Kump, Lei Miao, Ahmed S.A. Mady, +13

Journal of Medicinal Chemistry

The WD40 domain of FBXW7 is a poly(ADP-ribose)-binding domain that mediates the early DNA damage response

Qiang Zhang, Ahmed S.A. Mady, Yuanyuan Ma, +5

Nucleic Acids Research

ChromatinProtein FunctionDna DamageMolecular BiologyCell Death +8

Characterization of TioQ, a type II thioesterase from the thiocoraline biosynthetic cluster

Ahmed S.A. Mady, Olga E. Zolova, María Álvarez San Millán, +4

Molecular BioSystems

Adenylation-thiolation EnzymeBioorganic ChemistryEngineeringMolecular BiologyType Ii Thioesterase +19

Discovery of Mcl-1 inhibitors from integrated high throughput and virtual screening

Ahmed S.A. Mady, Chenzhong Liao, Naval Bajwa, +10

Scientific Reports

Directed Modulation of Protein Kinase C Isozyme Selectivity with Bisubstrate‐Based Inhibitors

Loek T. M. van Wandelen, Jeroen van Ameijde, Ahmed S.A. Mady, +5

ChemMedChem