Liselotte Angus

Protein engineering of novel plasminogen activators with increased thrombolytic potency in rabbits relative to activase

G R Larsen, Gregg Timony, P.G. Horgan et al. · Journal of Biological Chemistry · 1991 · 42 citations · Full text

Site-directed mutagenesis in human tissue-plasminogen activator. Distinguishing sites in the amino-terminal region required for full fibrinolytic activity and rapid clearance from the circulation.

Tim J. Ahern, G E Morris, K.M. Barone et al. · Journal of Biological Chemistry · 1990 · 34 citations · Full text

Fibrinolytic Activity, Molecular Biology, Rapid Clearance +24

Replacement of finger and growth factor domains of tissue plasminogen activator with plasminogen kringle 1. Biochemical and pharmacological characterization of a novel chimera containing a high affinity fibrin-binding domain linked to a heterologous protein

P R Langer-Safer, Tim J. Ahern, Liselotte Angus et al. · Journal of Biological Chemistry · 1991 · 13 citations · Full text