Sarah M. Bogner

Aurora A–Selective Inhibitor LY3295668 Leads to Dominant Mitotic Arrest, Apoptosis in Cancer Cells, and Shows Potent Preclinical Antitumor Efficacy

Jian Du, Lei Yan, Raquel Torres et al. · Molecular Cancer Therapeutics · 2019 · 52 citations · Full text

Medicine, Oncology, Pharmacology +15

Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor

Anke Klippel, Rui Wang, Loredana Puca et al. · Molecular Cancer Therapeutics · 2021 · 11 citations

Medicine, Oncology, Pharmacology +17

Abstract P4-08-02: LOXO-783: A potent, highly mutant selective and brain-penetrant allosteric PI3Kα H1047R inhibitor in combination with standard of care (SOC) treatments in preclinical PI3Kα H1047R-mutant breast cancer models

Loredana Puca, Michele Dowless, Carmen M. Perez-Ferreiro et al. · Cancer Research · 2023 · 10 citations

Medicine, Oncology, Pharmacology +15