Thienothiopyran-2-sulfonamides: a novel class of water-soluble carbonic anhydrase inhibitors

G. S. PONTICELLO, Mark B. Freedman, Charles N. Habecker, +6

Journal of Medicinal Chemistry

Inhibitory ActivityMedicinal ChemistryPharmaceutical ScienceBioorganic ChemistryCarbonic Anhydrase Activity +13

Topically active carbonic anhydrase inhibitors. 2. Benzo[b]thiophenesulfonamide derivatives with ocular hypotensive activity

Samuel Graham, Kenneth L. Shepard, Paul Anderson, +6

Journal of Medicinal Chemistry

Pharmaceutical ScienceOcular DiseaseOrganic ChemistryOcular Carbonic AnhydrasePharmacotherapy +15

Positions of His‐64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors

Graham Smith, Richard Alexander, David W. Christianson, +6

Protein Science

Inhibitors of gastric acid secretion: 3,4-diamino-1,2,5-thiadiazole 1-oxides and 1,1-dioxides as urea equivalents in a series of histamine H2 receptor antagonists

William C. Lumma, Paul Anderson, John J. Baldwin, +6

Journal of Medicinal Chemistry

Gastrointestinal PharmacologyGastric Acid SecretionGastroenterologyAltmetric Attention ScorePharmacotherapy +19

Utilization of .alpha.,.beta.-unsaturated acids as Michael acceptors for the synthesis of thieno[2,3-b]thiopyrans

G. S. PONTICELLO, Mark B. Freedman, Charles N. Habecker, +4

The Journal of Organic Chemistry

Natural Product SynthesisAltmetric Attention ScoreOrganic ChemistrySocial Media PresenceStereoselective Synthesis +7

.beta.1-Selective adrenoceptor antagonists: examples of the 2-[4-[3-(substituted amino)-2-hydroxypropoxy]phenyl]imidazole class. II

John J. Baldwin, Marcia E. Christy, George H. Denny, +7

Journal of Medicinal Chemistry

Molecular PharmacologyMedicinal ChemistryPharmaceutical ScienceBiochemistryMedicine +13

4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-one (L-691,121)

Jason Elliott, Harold G. Selnick, David A. Claremon, +6

Journal of Medicinal Chemistry

Pharmaceutical ScienceCardiovascular PharmacologyAltmetric Attention ScoreJason M. ElliottPharmacotherapy +15

An unusual dimer of 2-mercaptothiophene

G. S. PONTICELLO, Charles N. Habecker, Sándor Varga, +1

The Journal of Organic Chemistry

Altmetrics2-Mercaptothiophenegerald S. PonticelloEngineeringHeterocyclicInformation +10

Inhibitors of gastric acid secretion: antisecretory 2-pyridylurea derivatives

William A. Bolhofer, A. A. Deana, Charles N. Habecker, +7

Journal of Medicinal Chemistry

Gastrointestinal PharmacologyGastric Acid SecretionGastroenterologyPharmacotherapyExperimental Pharmacology +14

Conformational requirements for histamine H2-receptor inhibitors: a structure-activity study of phenylene analogs related to cimetidine and tiotidine

J. M. HOFFMAN, A. M. PIETRUSZKIEWICZ, Charles N. Habecker, +6

Journal of Medicinal Chemistry

Drug TargetPhenylene UnitPharmacotherapyChemical BiologyPharmaceutical Chemistry +19