Three Mammalian Lipins Act as Phosphatidate Phosphatases with Distinct Tissue Expression Patterns

Jimmy Donkor, Meltem Sarıahmetoğlu, Jay Dewald, +2

Journal of Biological Chemistry

Lpin1 GeneLipin Family MembersLipid MovementCellular PhysiologyInsulin Signaling +18

Phosphatidate Phosphohydrolase Catalyzes the Hydrolysis of Ceramide 1-Phosphate, Lysophosphatidate, and Sphingosine 1-Phosphate

David W. Waggoner, Antonio Gómez‐Muñoz, Jay Dewald, +1

Journal of Biological Chemistry

Lipid phosphate phosphohydrolase-1 degrades exogenous glycerolipid and sphingolipid phosphate esters

Renata Jasińska, Qiuxia Zhang, Carlos Pilquil, +8

Biochemical Journal

Lipid AnalysisProteinlipid InteractionSphingolipid Phosphate EstersCellular PhysiologyProtein Expression +17

A Conserved Serine Residue Is Required for the Phosphatidate Phosphatase Activity but Not the Transcriptional Coactivator Functions of Lipin-1 and Lipin-2

Jimmy Donkor, Peixiang Zhang, Samantha Wong, +5

Journal of Biological Chemistry

Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum

Jennifer R. Dwyer, Jimmy Donkor, Peixiang Zhang, +12

Proceedings of the National Academy of Sciences

Identification of structurally important domains of lipid phosphate phosphatase-1: implications for its sites of action

Qiuxia Zhang, Carlos Pilquil, Jay Dewald, +2

Biochemical Journal

Lipid Phosphate Phosphatase-1Proteinlipid InteractionSignal TransductionMolecular PhysiologyBiochemistry +13

Inhibition of autotaxin delays breast tumor growth and lung metastasis in mice

Matthew G.K. Benesch, Xiaoyun Tang, Tatsuo Maeda, +8

The FASEB Journal

FFA-induced hepatic insulin resistance in vivo is mediated by PKCδ, NADPH oxidase, and oxidative stress

Sandra Pereira, Edward Park, Yusaku Mori, +20

American Journal of Physiology-Endocrinology and Metabolism

Nadph OxidaseFatty Liver DiseaseInsulin SignalingOxidative StressInflammation +16

Lysophosphatidate signaling stabilizes Nrf2 and increases the expression of genes involved in drug resistance and oxidative stress responses: implications for cancer treatment

Ganesh Venkatraman, Matthew G.K. Benesch, Xiaoyun Tang, +3

The FASEB Journal

Tumor-induced inflammation in mammary adipose tissue stimulates a vicious cycle of autotaxin expression and breast cancer progression

Matthew G.K. Benesch, Xiaoyun Tang, Jay Dewald, +5

The FASEB Journal

Breast OncologyImmunologyAutotaxin ExpressionPathologyCancer Biology +21