Defen Lu

Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP

Guijun Shang, Deyu Zhu, Ning Li et al. · Nature Structural & Molecular Biology · 2012 · 225 citations

Biochemistry, Protein Assembly, Natural Sciences +5

Activation of STING by targeting a pocket in the transmembrane domain

Defen Lu, Guijun Shang, Jie Li et al. · Nature · 2022 · 159 citations · Full text

Signal Transduction, Membrane Transport, Transmembrane Domain +9

Characterization of Nuclear Localization Signal in the N Terminus of CUL4B and Its Essential Role in Cyclin E Degradation and Cell Cycle Progression

Yongxin Zou, Jun Mi, Jinpeng Cui et al. · Journal of Biological Chemistry · 2009 · 120 citations · Full text

A conserved ion channel function of STING mediates noncanonical autophagy and cell death

Jinrui Xun, Zhichao Zhang, Bo Lv et al. · EMBO Reports · 2024 · 76 citations · Full text

Structural Biochemistry of a Vibrio cholerae Dinucleotide Cyclase Reveals Cyclase Activity Regulation by Folates

Deyu Zhu, Lijun Wang, Guijun Shang et al. · Molecular Cell · 2014 · 74 citations · Full text

Biochemistry, Structural Biochemistry, Microbiology +2