Juan Pablo Millas-Vargas

FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via Sirt1/AMPK/β1-integrin pathway

Félix A. Urra, Felipe Muñoz, Miguel Córdova‐Delgado et al. · Scientific Reports · 2018 · 61 citations · Full text

Small structural changes on a hydroquinone scaffold determine the complex I inhibition or uncoupling of tumoral oxidative phosphorylation

Félix A. Urra, Miguel Córdova‐Delgado, Michel Lapier et al. · Toxicology and Applied Pharmacology · 2015 · 33 citations · Full text

Small Structural Changes, Biochemistry, Mechanism Of Action +10

Synthesis of antiplatelet ortho-carbonyl hydroquinones with differential action on platelet aggregation stimulated by collagen or TRAP-6

Diego Méndez, Félix A. Urra, Juan Pablo Millas-Vargas et al. · European Journal of Medicinal Chemistry · 2020 · 28 citations · Full text

Differential Action, Thrombopoiesis, Biochemistry +4

An acylhydroquinone derivative produces OXPHOS uncoupling and sensitization to BH3 mimetic ABT-199 (Venetoclax) in human promyelocytic leukemia cells

Viviana Donoso-Bustamante, Edgar A. Borrego, Yareli Schiaffino-Bustamante et al. · Bioorganic Chemistry · 2020 · 18 citations · Full text

Hematological Malignancy, Oxphos Uncoupling, Biochemistry +7

Synthesis and pharmacological evaluation of acylhydroquinone derivatives as potent antiplatelet agents

Diego Méndez, Viviana Donoso-Bustamante, Juan Pablo Millas-Vargas et al. · Biochemical Pharmacology · 2020 · 15 citations

Molecular Pharmacology, Pharmaceutical Science, Medicine +8