P H Hirel

Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid.

P H Hirel, M J Schmitter, P Dessen et al. · Proceedings of the National Academy of Sciences · 1989 · 760 citations · Full text

Engineering, Bacteriology, Molecular Biology +17

Sensitive, soluble chromogenic substrates for HIV-1 proteinase.

Anthony D. Richards, Lowri H. Phylip, William G. Farmerie et al. · Journal of Biological Chemistry · 1990 · 199 citations · Full text

Protein Chemistry, Kappa Cat, Viral Replication +14

The three-dimensional structure of the aspartyl protease from the HIV-1 isolate BRU

S. Spinelli, Qi‐Jun Liu, Pedro M. Alzari et al. · Biochimie · 1991 · 185 citations

Protein Chemistry, Virus Structure, Protein Assembly +13

Genetic engineering of methionyl-tRNA synthetase: in vitro regeneration of an active synthetase by proteolytic cleavage of a methionyl-tRNA synthetase-β-galactosidase chimeric protein

P H Hirel, Françoise Lévêque, Patrice Mellot et al. · Biochimie · 1988 · 53 citations

Transgenic Technology, Vitro Regeneration, Engineering +10

HIV-1 Aspartic Proteinase: High-Level Production and Automated Fluorometric Screening Assay of Inhibitors

P H Hirel, Fabienne Parker, Janine Boiziau et al. · Antiviral chemistry & chemotherapy · 1990 · 19 citations

Molecular Biology, Peptide Science, Analytical Ultracentrifugation +20