Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: a new pathway connecting inflammation to cancer

Elisa Brighenti, Carlo Calabrese, Giuseppina Liguori, +4

Oncogene

Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade

Simona Tavolari, Massimiliano Bonafè, Marina Marini, +7

Carcinogenesis

High prevalence of retinoblastoma protein loss in triple-negative breast cancers and its association with a good prognosis in patients treated with adjuvant chemotherapy

Davide Treré, Elisa Brighenti, Giulio Donati, +5

Annals of Oncology

Breast OncologyMedicineAdjuvant ChemotherapyPathologyHigh Prevalence +5

Selective inhibition of rRNA transcription downregulates E2F-1: a new p53-independent mechanism linking cell growth to cell proliferation

Giulio Donati, Elisa Brighenti, Manuela Vici, +4

Journal of Cell Science

Molecular BiologyTumour Suppressor P53Tumor BiologyCell RegulationCell Signaling +14

The balance between rRNA and ribosomal protein synthesis up- and downregulates the tumour suppressor p53 in mammalian cells

Giulio Donati, Serena Bertoni, Elisa Brighenti, +5

Oncogene

Tumor BiologyMammalian CellsMedicineTumour Suppressor P53Ribosomal Protein Synthesis +6

Direct relationship between the level of p53 stabilization induced by rRNA synthesis-inhibiting drugs and the cell ribosome biogenesis rate

Federico Scala, Elisa Brighenti, Marzia Govoni, +5

Oncogene

Direct RelationshipMolecular BiologyTumor SuppressorRrna Synthesis-inhibiting DrugsP53 Stabilization +3

Constitutive activation of the DNA damage response pathway as a novel therapeutic target in diffuse large B-cell lymphoma

Enrico Derenzini, Claudio Agostinelli, Enrica Imbrogno, +10

Oncotarget

The p53‐mediated sensitivity of cancer cells to chemotherapeutic agents is conditioned by the status of the retinoblastoma protein

Massimo Derenzini, Elisa Brighenti, Giulio Donati, +6

The Journal of Pathology

Therapeutic dosages of aspirin counteract the IL-6 induced pro-tumorigenic effects by slowing down the ribosome biogenesis rate

Elisa Brighenti, F.A. Giannone, Francesca Fornari, +5

Oncotarget

Chemoprevention StrategyRibosome Biogenesis RateImmunologyCell DeathCancer Biology +15

The inhibition of lactate dehydrogenase A hinders the transcription of histone 2B gene independently from the block of aerobic glycolysis

Elisa Brighenti, Domenica Carnicelli, Maurizio Brigotti, +1

Biochemical and Biophysical Research Communications

Histone ModificationsChromatinBiochemistryAerobic GlycolysisNatural Sciences +10