Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

Marko Škrtić, Shrivani Sriskanthadevan, Bozhena Jhas, +26

Cancer Cell

Hematological MalignancyTranslational MedicineMitochondrial FunctionMitochondrial TranslationMedicine +8

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

Alicia M. Cole, Zezhou Wang, Étienne Coyaud, +35

Cancer Cell

Hematological MalignancyMitochondrial FunctionMitochondrial Protease ClppMedicineMalignant Blood Disorder +8

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

Jo Ishizawa, Sarah F. Zarabi, R. Eric Davis, +29

Cancer Cell

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

Shrivani Sriskanthadevan, Danny V. Jeyaraju, Timothy Chung, +20

Blood

Activated, But Not Resting, T Cells Can Be Recognized and Killed by Syngeneic NK Cells

Brian Rabinovich, Jennifer Li, John P. Shannon, +4

The Journal of Immunology

A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death

Tabitha E. Wood, Shadi Dalili, Craig D. Simpson, +10

Molecular Cancer Therapeutics

Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells

Yanina Eberhard, Sean McDermott, Xiaoming Wang, +10

Blood

Targeting Mitochondria with Avocatin B Induces Selective Leukemia Cell Death

Eric A. Lee, Leonard Angka, Sarah-Grace Rota, +17

Cancer Research

Hematological MalignancyMitophagyAvocatin BMitochondrial FunctionMedicine +11

The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma

G. Wei Xu, Mohsin Ali, Tabitha E. Wood, +17

Blood

Wnt Inhibitor Screen Reveals Iron Dependence of β-Catenin Signaling in Cancers

Siyuan Song, Tania Christova, Stephen Perusini, +17

Cancer Research

Tumor BiologySignaling PathwayIron ChelationIron Metabolismβ-Catenin Signaling +12