Oncogenic AURKA-enhanced N6-methyladenosine modification increases DROSHA mRNA stability to transactivate STC1 in breast cancer stem-like cells

Fei Peng, Jie Xu, Bai Cui, +24

Cell Research

Breast OncologyOncogenic AgentMedicineBreast CancerCell Biology +6

Target Enzyme‐Activated Two‐Photon Fluorescent Probes: A Case Study of CYP3A4 Using a Two‐Dimensional Design Strategy

Jing Ning, Wei Wang, Guang‐Bo Ge, +7

Angewandte Chemie International Edition

Target EnzymeIdeal SelectivityEngineeringMolecular BiologyChemical Biology +18

EGCG protects against homocysteine-induced human umbilical vein endothelial cells apoptosis by modulating mitochondrial-dependent apoptotic signaling and PI3K/Akt/eNOS signaling pathways

Shumin Liu, Zhengwu Sun, Peng Chu, +10

APOPTOSIS

Mitochondrial-dependent Apoptotic SignalingSignal TransductionMitochondrial FunctionLipid PeroxidationApoptosis +10

Phosphocreatine protects endothelial cells from oxidized low-density lipoprotein-induced apoptosis by modulating the PI3K/Akt/eNOS pathway

Anil Ahsan, Guozhu Han, Pan Jun-fang, +10

APOPTOSIS

OxysterolEndothelial CellsCell SignalingMedicineApoptosis +11

Phosphocreatine protects endothelial cells from Methylglyoxal induced oxidative stress and apoptosis via the regulation of PI3K/Akt/eNOS and NF-κB pathway

Peng Chu, Guozhu Han, Anil Ahsan, +7

Vascular Pharmacology

InflammationRedox SignalingMolecular PhysiologyEndothelial CellsMedicine +13

SZC015, a synthetic oleanolic acid derivative, induces both apoptosis and autophagy in MCF-7 breast cancer cells

Jingjun Wu, Chun Yang, Chao Guo, +13

Chemico-Biological Interactions

Tumor BiologyMitophagyCell AutophagyMedicineApoptosis +9

Highly Selective NIR Probe for Intestinal β-Glucuronidase and High-Throughput Screening Inhibitors to Therapy Intestinal Damage

Lei Feng, Yongliang Yang, Xiaokui Huo, +9

ACS Sensors

A deubiquitination module essential for T _reg fitness in the tumor microenvironment

Elena Montauti, Samuel E. Weinberg, Peng Chu, +14

Science Advances

SZC017, a novel oleanolic acid derivative, induces apoptosis and autophagy in human breast cancer cells

Lei Gao, Yan Wang, Zhen Xu, +11

APOPTOSIS

Cell AutophagyOncogenic AgentMedicineInduces ApoptosisAutophagy +6

Phosphocreatine protects against LPS-induced human umbilical vein endothelial cell apoptosis by regulating mitochondrial oxidative phosphorylation

Zhengwu Sun, Xiaoyan Lan, Anil Ahsan, +9

APOPTOSIS

OxysterolMitochondrial FunctionApoptosisPhysiologyEndothelial Dysfunction +7