Christine A. Penfold

Conformation of the Human Immunoglobulin G2 Hinge Imparts Superagonistic Properties to Immunostimulatory Anticancer Antibodies

Ann L. White, H.T. Claude Chan, Ruth R. French et al. · Cancer Cell · 2014 · 171 citations · Full text

Pharmacy, Immunology, Oncology +14

Antibodies to Costimulatory Receptor 4-1BB Enhance Anti-tumor Immunity via T Regulatory Cell Depletion and Promotion of CD8 T Cell Effector Function

Sarah L. Buchan, Lang Dou, Marcus Remer et al. · Immunity · 2018 · 153 citations · Full text

Life Sciences, Immunology, Oncology +14

Reducing affinity as a strategy to boost immunomodulatory antibody agonism

Xiaojie Yu, Christian M. Orr, H.T. Claude Chan et al. · Nature · 2023 · 116 citations · Full text

Pharmacy, Immunology, Pharmacology +12

PD-1 Blockade and CD27 Stimulation Activate Distinct Transcriptional Programs That Synergize for CD8+ T-Cell–Driven Antitumor Immunity

Sarah L. Buchan, Mohannad Fallatah, Stephen M. Thirdborough et al. · Clinical Cancer Research · 2018 · 112 citations · Full text

Life Sciences, Immunology, Oncology +17

Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies

Xiaojie Yu, H.T. Claude Chan, Christian M. Orr et al. · Cancer Cell · 2018 · 111 citations · Full text

Pharmacy, Immunology, Pharmacology +17