Combined effects of angiostatin and ionizing radiation in antitumour therapy

Helena J. Mauceri, Nader Hanna, Michael A. Beckett, +11

Nature

Nuclear MedicineRadiation TherapyMedicineRadionuclide TherapyBrachytherapy +7

The mechanism of cancer-mediated conversion of plasminogen to the angiogenesis inhibitor angiostatin

Stephen Gately, Przemyslaw Twardowski, M. Sharon Stack, +10

Proceedings of the National Academy of Sciences

Inhibition of angiogenesis and tumor growth in the brain. Suppression of endothelial cell turnover by penicillamine and the depletion of copper, an angiogenic cofactor.

Steven Brem, David Zagzag, Ana Maria Crous Tsanaclis, +3

PubMed

Human prostate carcinoma cells express enzymatic activity that converts human plasminogen to the angiogenesis inhibitor, angiostatin.

Stephen Gately, P. Twardowski, M. Sharon Stack, +10

PubMed

Angiogenesis InhibitorCancer BiologyTumor BiologyAngiogenesisSerine Proteinase +16

Potentiation of the antitumor effect of ionizing radiation by brief concomitant exposures to angiostatin.

David H. Gorski, Helena J. Mauceri, Rabih M. Salloum, +7

PubMed

Radiation EffectRadiation ExposurePathologyRadiation BiologyBrief Concomitant Exposures +18

Novel therapeutics with enhanced biological activity generated by the strategic introduction of silicon isosteres into known drug scaffolds

Stephen Gately, Robert West

Drug Development Research

Pharmaceutical ScienceNanotherapeuticsEngineeringChemoprevention StrategyBiofabrication +17

β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

Danielle Frost, Bessie Meechoovet, Tong Wang, +4

PLoS ONE

Synaptic SignalingTau ProteinSerine 396Social SciencesMolecular Pharmacology +19

Expression of plasminogen activator inhibitor type 1 by human prostate carcinoma cells inhibits primary tumor growth, tumor-associated angiogenesis, and metastasis to lung and liver in an athymic mouse model.

Gerald A. Soff, J Sanderowitz, Stephen Gately, +4

Journal of Clinical Investigation

Lung MetastasesPrimary Tumor GrowthCancer BiologyTumor BiologyGenitourinary Cancer +15

Suramin, an anticancer and angiosuppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urokinase-type plasminogen activator.

Shingo Takano, Stephen Gately, Mary E. Neville, +6

PubMed

Endothelial Cell BindingPathologyPharmacotherapyBiomedical EngineeringTumor Biology +18

Antiangiogenic scheduling of lower dose cancer chemotherapy.

Stephen Gately, R.S. Kerbel

PubMed

Selective Angiogenesis InhibitorOncologyAntiangiogenic SchedulingMetronomic TherapyPharmacology +11