Isabel Freund

Next‐Generation Sequencing‐Based RiboMethSeq Protocol for Analysis of tRNA 2′‐O‐Methylation

Virginie Marchand, Florian Pichot, Kathrin Thüring et al. · Biomolecules · 2017 · 67 citations · Full text

Bacterial tRNA 2′-O-methylation is dynamically regulated under stress conditions and modulates innate immune response

Adeline Galvanin, Lea‐Marie Vogt, Antonia Grober et al. · Nucleic Acids Research · 2020 · 51 citations · Full text

2′-<i>O</i>-methylation within prokaryotic and eukaryotic tRNA inhibits innate immune activation by endosomal Toll-like receptors but does not affect recognition of whole organisms

Isabel Freund, Daniel K. Buhl, Sébastien Boutin et al. · RNA · 2019 · 35 citations · Full text

Double methylation of tRNA-U54 to 2′-O-methylthymidine (Tm) synergistically decreases immune response by Toll-like receptor 7

Patrick Keller, Isabel Freund, Virginie Marchand et al. · Nucleic Acids Research · 2018 · 30 citations · Full text

Adaptive Immune System, Viral Immunity, Immunology +20

Identification of an optimized 2′-<i>O</i>-methylated trinucleotide RNA motif inhibiting Toll-like receptors 7 and 8

Felix C. F. Schmitt, Isabel Freund, Markus A. Weigand et al. · RNA · 2017 · 26 citations · Full text