Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Abhishek Jha, Stanley Ching‐Cheng Huang, Alexey Sergushichev, +10

Immunity

Transcriptional RegulationSystems BiologyFunctional GenomicsMetabolic NetworkNatural Sciences +13

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

Vicky Lampropoulou, Alexey Sergushichev, Monika Bambousková, +15

Cell Metabolism

InflammationSuccinate DehydrogenaseMacrophage Metabolic RemodelingAnti-inflammatoryItaconate Links Inhibition +10

TREM2 Maintains Microglial Metabolic Fitness in Alzheimer’s Disease

Tyler K. Ulland, Wilbur M. Song, Stanley Ching‐Cheng Huang, +16

Cell

Neurodegenerative DiseasesAlzheimer's DiseaseMedicineBrain-immune InteractionAlzheimer ’ +5

Electrophilic properties of itaconate and derivatives regulate the IκBζ–ATF3 inflammatory axis

Monika Bambousková, Laurent Gorvel, Vicky Lampropoulou, +28

Nature

InflammationCytokineInflammatory DiseaseSignal TransductionImmunology +10

Mitochondrial Phosphoenolpyruvate Carboxykinase Regulates Metabolic Adaptation and Enables Glucose-Independent Tumor Growth

Emma E. Vincent, Alexey Sergushichev, Takla Griss, +17

Molecular Cell

Mitochondrial FunctionBiochemistryMedicineMitochondrial DynamicPhysiology +7

<i>Irg1</i> expression in myeloid cells prevents immunopathology during <i>M. tuberculosis</i> infection

Sharmila Nair, Jeremy Huynh, Vicky Lampropoulou, +10

The Journal of Experimental Medicine

Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes

Nicole C. Howard, Nancy D. Marín, Mushtaq Ahmed, +18

Nature Microbiology

Medical MicrobiologyPulmonary TuberculosisHealth SciencesMycobacterium TuberculosisImmunology +8

Homeostatic Control of Innate Lung Inflammation by Vici Syndrome Gene Epg5 and Additional Autophagy Genes Promotes Influenza Pathogenesis

Qun Lu, Christine C. Yokoyama, Jesse W. Williams, +23

Cell Host & Microbe

Innate Lung InflammationInflammatory Lung DiseaseLung InflammationInnate Immune SystemImmunology +4

The miR-17∼92 microRNA Cluster Is a Global Regulator of Tumor Metabolism

Said Izreig, Bożena Samborska, Radia Marie Johnson, +11

Cell Reports

LKB1 deficiency in T cells promotes the development of gastrointestinal polyposis

Maya C. Poffenberger, Avril Metcalfe‐Roach, Esther Aguilar, +21

Science