Inflammation induced by influenza virus impairs human innate immune control of pneumococcus

Simon P. Jochems, Fernando Marcon, Beatriz F. Carniel, +21

Nature Immunology

InflammationHost ResponsePathogenesisImmunologyInnate Immune System +6

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

Tina Seitz, Robert Stalmann, Nawar Dalila, +6

Genome Medicine

Interaction between the nasal microbiota and S. pneumoniae in the context of live-attenuated influenza vaccine

Wouter A. A. de Steenhuijsen Piters, Simon P. Jochems, Elena Mitsi, +11

Nature Communications

Microbial PathogensImmunologyS. PneumoniaeNasal Microbiota ProfilesBacterial Pathogens +15

Increased Systemic Exposure and Stronger Cardiovascular and Metabolic Adverse Reactions to Fenoterol in Individuals with Heritable <i>OCT1</i> Deficiency

Mladen V. Tzvetkov, Johannes Matthaei, Sherin Pojar, +5

Clinical Pharmacology & Therapeutics

Microinvasion by Streptococcus pneumoniae induces epithelial innate immunity during colonisation at the human mucosal surface

Caroline M. Weight, Cristina Venturini, Sherin Pojar, +8

Nature Communications

Polysaccharide-Specific Memory B Cells Predict Protection against Experimental Human Pneumococcal Carriage

Shaun H. Pennington, Sherin Pojar, Elena Mitsi, +11

American Journal of Respiratory and Critical Care Medicine

Innate and adaptive nasal mucosal immune responses following experimental human pneumococcal colonization

Simon P. Jochems, Karin de Ruiter, Carla Solórzano, +24

Journal of Clinical Investigation

InflammationStreptococcus PneumoniaeBlood MucosalMucosal ImmunologyInnate Immune System +13

Nasal Pneumococcal Density Is Associated with Microaspiration and Heightened Human Alveolar Macrophage Responsiveness to Bacterial Pathogens

Elena Mitsi, Beatriz F. Carniel, Jesús Reiné, +17

American Journal of Respiratory and Critical Care Medicine

Pneumococcal Colonization in Healthy Adult Research Participants in the Conjugate Vaccine Era, United Kingdom, 2010–2017

Hugh Adler, Elissavet Nikolaou, Katherine A. Gould, +15

The Journal of Infectious Diseases

Pathogenic MicrobiologyUnited KingdomPneumococcal ColonizationVaccine HesitancyBacterial Pathogens +19

Experimental Human Pneumococcal Colonization in Older Adults Is Feasible and Safe, Not Immunogenic

Hugh Adler, Esther L. German, Elena Mitsi, +26

American Journal of Respiratory and Critical Care Medicine