substituted (S)-Phenylpiperidines and Rigid Congeners as Preferential Dopamine Autoreceptor Antagonists: Synthesis and Structure-Activity Relationships

Clas Sonesson, Chiu‐Hong Lin, Lars O. Hansson, +5

Journal of Medicinal Chemistry

Molecular PharmacologyCentral DopamineBiochemistryRigid CongenersPreferential Dopamine Autoreceptor +13

The dopaminergic stabilizers pridopidine (ACR16) and (−)-OSU6162 display dopamine D2 receptor antagonism and fast receptor dissociation properties

Tino Dyhring, Elsebet Ø. Nielsen, Clas Sonesson, +5

European Journal of Pharmacology

Molecular PharmacologyMedicinePsychopharmacologyNeuropharmacologyNeuroscience +6

Regiochemical Control and Suppression of Double Bond Isomerization in the Heck Arylation of 1-(Methoxycarbonyl)-2,5-dihydropyrrole

Clas Sonesson, Mats Larhed, Camilla Nyqvist, +1

The Journal of Organic Chemistry

EngineeringOrganic ChemistrySilver CarbonateChemistryHeterocycle Chemistry +16

Efficacy and Safety of the Dopaminergic Stabilizer Pridopidine (ACR16) in Patients With Huntington's Disease

Anders Lundin, Espen Dietrichs, Sara Haghighi, +10

Clinical Neuropharmacology

Differential effects of dopamine D2 and D3 receptor antagonists in regard to dopamine release, in vivo receptor displacement and behaviour

Nicholas Waters, L. L�fberg, Susanne R. Haadsma‐Svensson, +3

Journal of Neural Transmission

Behavioral SciencesNeuropsychologyBehavioral NeuroscienceFunctional SelectivityBehavioural Pharmacology +12

In vivo pharmacology of the dopaminergic stabilizer pridopidine

Henrik Pontén, Johan Kullingsjö, Sören Lagerkvist, +4

European Journal of Pharmacology

PsychopharmacologyPharmacotherapyExperimental PharmacologySocial SciencesNeurochemistry +14

Synthesis and Evaluation of a Set of 4-Phenylpiperidines and 4-Phenylpiperazines as D₂Receptor Ligands and the Discovery of the Dopaminergic Stabilizer 4-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine (Huntexil, Pridopidine, ACR16)

Fredrik Pettersson, Henrik Pontén, Nicholas Waters, +1

Journal of Medicinal Chemistry

BiochemistryFunctional SelectivityDopaminergic StabilizerMedicineBehavioral Pharmacology +12

2-Alkyl-3-(1,2,3,6-tetrahydropyridin-4-yl)-1H-indoles as novel 5-HT6 receptor agonists

Cecilia Mattsson, Clas Sonesson, Anna Sandahl, +5

Bioorganic & Medicinal Chemistry Letters

BiochemistryFunctional SelectivityMedicineMechanism Of ActionReceptor (Biochemistry) +2

Effects of the substituted (S)-3-phenylpiperidine (?)-OSU6162 on PET measurements in subhuman primates: Evidence for tone-dependent normalization of striatal dopaminergic activity

Joakim Tedroff, Richard Torstenson, Per Hartvig, +6

Synapse

Striatal Dopaminergic ActivityNeurotransmitterPet MeasurementsPositron Emission TomographyNeurochemistry +16

Long-lasting improvement following (-)-OSU6162 in a patient with Huntington’s disease

Joakim Tedroff, Anna Ekesbo, Clas Sonesson, +2

Neurology

Psychotropic MedicationLong-lasting ImprovementNeurotransmitterClinical NeuroscienceSynaptic Signaling +22