David J. Daniels

Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series

David J. Daniels, Natalie R. Lenard, Chris Etienne et al. · Proceedings of the National Academy of Sciences · 2005 · 291 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

A Bivalent Ligand (KDN-21) Reveals Spinal δ and κ Opioid Receptors Are Organized as Heterodimers That Give Rise to δ₁ and <i>κ</i>₂ Phenotypes. Selective Targeting of δ−κ Heterodimers

Rashmi G. Bhushan, Shiv K. Sharma, Zhihua Xie et al. · Journal of Medicinal Chemistry · 2004 · 130 citations · Full text

Medicine, Neuroscience, Pharmacology +17

A Bivalent Ligand (KDAN-18) Containing δ-Antagonist and κ-Agonist Pharmacophores Bridges δ₂ and κ₁ Opioid Receptor Phenotypes

David J. Daniels, Amol A. Kulkarni, Zhihua Xie et al. · Journal of Medicinal Chemistry · 2004 · 116 citations

Medicine, Medicinal Chemistry, Pharmacology +17

H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers

Fang Dong, Haiyun Gan, Liang Cheng et al. · eLife · 2018 · 102 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Absence of conditioned place preference or reinstatement with bivalent ligands containing mu-opioid receptor agonist and delta-opioid receptor antagonist pharmacophores

Natalie R. Lenard, David J. Daniels, Philip S. Portoghese et al. · European Journal of Pharmacology · 2007 · 82 citations

Medicine, Pharmacology, Behavioral Pharmacology +15