Yuqing Xie

Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery

Li Tang, Yiran Zheng, Mariane B. Melo et al. · Nature Biotechnology · 2018 · 623 citations · Full text

T Cell Therapy, Nanomedicine, Cell-based Drug Delivery +4

Metabolic reprogramming of terminally exhausted CD8+ T cells by IL-10 enhances anti-tumor immunity

Yugang Guo, Yuqing Xie, Min Gao et al. · Nature Immunology · 2021 · 390 citations · Full text

Inflammation, Cancer Immunosurveillance, Metabolic Reprogramming +9

Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy

Kewen Lei, Armand Kurum, Murat Kaynak et al. · Nature Biomedical Engineering · 2021 · 230 citations · Full text

Cancer Immunosurveillance, T-regulatory Cell, Immunology +6

IL-10-expressing CAR T cells resist dysfunction and mediate durable clearance of solid tumors and metastases

Yang Zhao, Jiangqing Chen, Massimo Andreatta et al. · Nature Biotechnology · 2024 · 212 citations · Full text

Cancer Immunosurveillance, Mediate Durable Clearance, Solid Tumors +8

The type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer

Bing Feng, Zhiliang Bai, Xiaolei Zhou et al. · Nature · 2024 · 98 citations · Full text

Cytokine, Cancer Immunosurveillance, Adaptive Immune System +12