Minghong Lan

Oxygen‐Sensing Nox4 Generates Genotoxic ROS to Induce Premature Senescence of Nucleus Pulposus Cells through MAPK and NF‐<i>κ</i>B Pathways

Chencheng Feng, Yang Zhang, Minghui Yang et al. · Oxidative Medicine and Cellular Longevity · 2017 · 70 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Cyclic mechanical tension reinforces DNA damage and activates the p53-p21-Rb pathway to induce premature senescence of nucleus pulposus cells

Chencheng Feng, Minghui Yang, Yang Zhang et al. · International Journal of Molecular Medicine · 2018 · 54 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

The matrikine N-acetylated proline-glycine-proline induces premature senescence of nucleus pulposus cells via CXCR1-dependent ROS accumulation and DNA damage and reinforces the destructive effect of these cells on homeostasis of intervertebral discs

Chencheng Feng, Yang Zhang, Minghui Yang et al. · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · 2016 · 31 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17

Collagen-derived N-acetylated proline-glycine-proline upregulates the expression of pro-inflammatory cytokines and extracellular matrix proteases in nucleus pulposus cells via the NF-κB and MAPK signaling pathways

Chencheng Feng, Jinyue He, Yang Zhang et al. · International Journal of Molecular Medicine · 2017 · 19 citations · Full text

Life Sciences, Cell Biology, Immunology +17

Transcriptome and alternative splicing analysis of nucleus pulposus cells in response to high oxygen tension: Involvement of high oxygen tension in the pathogenesis of intervertebral disc degeneration

Chencheng Feng, Yang Zhang, Minghui Yang et al. · International Journal of Molecular Medicine · 2018 · 11 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15