CD44 Variant Regulates Redox Status in Cancer Cells by Stabilizing the xCT Subunit of System xc− and Thereby Promotes Tumor Growth

Takatsugu Ishimoto, Osamu Nagano, Toshifumi Yae, +18

Cancer Cell

OncologyRedox RegulatorMedicineCancer Cell BiologyXct Subunit +9

Alternative splicing of CD44 mRNA by ESRP1 enhances lung colonization of metastatic cancer cell

Toshifumi Yae, Kenji Tsuchihashi, Takatsugu Ishimoto, +17

Nature Communications

MedicineCd44 MrnaCancer Cell BiologyAlternative SplicingEsrp1 Enhances +7

xCT Inhibition Depletes CD44v-Expressing Tumor Cells That Are Resistant to EGFR-Targeted Therapy in Head and Neck Squamous Cell Carcinoma

Momoko Yoshikawa, Kenji Tsuchihashi, Takatsugu Ishimoto, +13

Cancer Research

Salt-Inducible Kinase 2 Couples Ovarian Cancer Cell Metabolism with Survival at the Adipocyte-Rich Metastatic Niche

Fabrizio Miranda, David Mannion, Shujuan Liu, +32

Cancer Cell

Salt-inducible Kinase 2Adipocyte-rich Metastatic NicheMedicineReceptor Tyrosine KinaseCancer Cell Biology +10

The impact of EpCAM expression on response to chemotherapy and clinical outcomes in patients with epithelial ovarian cancer

Shingo Tayama, Takeshi Motohara, Dashdemberel Narantuya, +7

Oncotarget

Epithelial Ovarian CancerMedicineCancer ManagementImmunologyGynecology +13

<scp>CD</scp>44 variant 6 is correlated with peritoneal dissemination and poor prognosis in patients with advanced epithelial ovarian cancer

Francisca Tjhay, Takeshi Motohara, Shingo Tayama, +7

Cancer Science

Onionin A inhibits ovarian cancer progression by suppressing cancer cell proliferation and the protumour function of macrophages

Junko Tsuboki, Yukio Fujiwara, Hasita Horlad, +12

Scientific Reports

Transient depletion of p53 followed by transduction of c-Myc and K-Ras converts ovarian stem-like cells into tumor-initiating cells

Takeshi Motohara, Sachiko Masuko, Takatsugu Ishimoto, +9

Carcinogenesis

Normal MouseLineage PlasticityTransient DepletionTumor-initiating CellsMedicine +12

Adipocyte-like signature in ovarian cancer minimal residual disease identifies metabolic vulnerabilities of tumor initiating cells

Mara Artibani, Kenta Masuda, Zhiyuan Hu, +28

JCI Insight

Metabolic DisorderAdipocyte-like SignaturePathologyMetabolic RemodelingCancer Biology +17

Polycystic ovary syndrome: early diagnosis and intervention are necessary for fertility preservation in young women with endometrial cancer under 35 years of age

Yoshinori Okamura, Fumitaka Saito, Kiyomi Takaishi, +4

Reproductive Medicine and Biology

FertilityReproductive HealthGynecologyPolycystic Ovary SyndromeFemale Reproductive System +24