Hein Than

A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer

King Pan Ng, Axel M. Hillmer, Charles Chuah et al. · Nature Medicine · 2012 · 554 citations

Medicine, Molecular Biology, Oncology +17

Combining the Allosteric Inhibitor Asciminib with Ponatinib Suppresses Emergence of and Restores Efficacy against Highly Resistant BCR-ABL1 Mutants

Christopher A. Eide, Matthew S. Zabriskie, Samantha L. Savage et al. · Cancer Cell · 2019 · 245 citations · Full text

Medicine, Pharmacology, Pharmacotherapy +11

SIRT5 Is a Druggable Metabolic Vulnerability in Acute Myeloid Leukemia

Dongqing Yan, Anca Franzini, Anthony D. Pomicter et al. · Blood Cancer Discovery · 2021 · 59 citations · Full text

Life Sciences, Cancer Biology, Oncology +17

Pyrvinium selectively targets blast phase-chronic myeloid leukemia through inhibition of mitochondrial respiration

Wei Xiang, Jit Kong Cheong, Shi Hui Ang et al. · Oncotarget · 2015 · 58 citations · Full text

Medicine, Oncology, Pharmacology +13

The transcriptome of CMML monocytes is highly inflammatory and reflects leukemia-specific and age-related alterations

Anca Franzini, Anthony D. Pomicter, Dongqing Yan et al. · Blood Advances · 2019 · 54 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15