Francis J. Roushar

Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning

Wesley D. Penn, Andrew G. McKee, Charles P. Kuntz et al. · Science Advances · 2020 · 57 citations · Full text

Proteinlipid Interaction, Protein Assembly, Biomolecular Structure Prediction +18

Contribution of Cotranslational Folding Defects to Membrane Protein Homeostasis

Francis J. Roushar, Timothy C. Gruenhagen, Wesley D. Penn et al. · Journal of the American Chemical Society · 2018 · 31 citations · Full text

Proteinlipid Interaction, Topological Energetics, Protein Function +14

General trends in the effects of VX-661 and VX-445 on the plasma membrane expression of clinical CFTR variants

Andrew G. McKee, Eli Fritz McDonald, Wesley D. Penn et al. · Cell chemical biology · 2023 · 29 citations · Full text

The Retinitis Pigmentosa-Linked Mutations in Transmembrane Helix 5 of Rhodopsin Disrupt Cellular Trafficking Regardless of Oligomerization State

D. Paul Mallory, Elizabeth Gutierrez, Margaret Pinkevitch et al. · Biochemistry · 2018 · 22 citations · Full text

Proteinlipid Interaction, Protein Assembly, Molecular Biology +19

Systematic profiling of temperature- and retinal-sensitive rhodopsin variants by deep mutational scanning

Andrew G. McKee, Charles P. Kuntz, Joseph T. Ortega et al. · Journal of Biological Chemistry · 2021 · 17 citations · Full text

Genetics, Molecular Biology, Retinal-sensitive Rhodopsin Variants +17