Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models

Massimo Zollo, Valeria Di Dato, Daniela Spano, +9

Clinical & Experimental Metastasis

MedicineBindarit InducesTumor TargetingRadiation OncologyCancer Biology +3

Amelioration of alphavirus‐induced arthritis and myositis in a mouse model by treatment with bindarit, an inhibitor of monocyte chemotactic proteins

Nestor E. Rulli, Angelo Guglielmotti, Giorgina Mangano, +5

Arthritis & Rheumatism

Impact of the anti-inflammatory agent bindarit on the chemokinome: selective inhibition of the monocyte chemotactic proteins.

Massimiliano Mirolo, Marco Fabbri, Marina Sironi, +6

PubMed

Chemokine BiologyEndothelial CellsImmunologyImmune RegulationImmunotherapy +17

The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice

Gianluca Grassia, M. Maddaluno, Angelo Guglielmotti, +4

Cardiovascular Research

New anti-viral drugs for the treatment of the common cold

Caterina Maugeri, Maria Alessandra Alisi, Claudia Apicella, +7

Bioorganic & Medicinal Chemistry

Antiviral AgentsMedicineAntiviral Drug DevelopmentAntiviral ResponseAntiviral Therapy +6

Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro

Annalisa Bruno, Luigia Di Francesco, Isabella Coletta, +11

Biochemical Pharmacology

Medicinal ChemistryNovel InhibitorHuman MonocytesBiochemistryMedicine +8

Regulation of the microsomal prostaglandin E synthase-1 in polarized mononuclear phagocytes and its constitutive expression in neutrophils

M. Mosca, Nadia Polentarutti, Giorgina Mangano, +10

Journal of Leukocyte Biology

ImmunologyImmune RegulationCellular PhysiologyInflammationConstitutive Expression +18

Pharmacological Inhibition of Microsomal Prostaglandin E Synthase-1 Suppresses Epidermal Growth Factor Receptor-Mediated Tumor Growth and Angiogenesis

Federica Finetti, Erika Terzuoli, Isabella Coletta, +7

PLoS ONE

Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors

Noemi D’Atanasio, Alessandra Capezzone de Joannon, Laura Di Sante, +10

PLoS ONE

Inhibitory ActivityAntimicrobial Drug DiscoveryAntimicrobial SusceptibilityMedicineAntibacterial Activity +12

Hit Optimization of 5-Substituted-<i>N</i>-(piperidin-4-ylmethyl)-1<i>H</i>-indazole-3-carboxamides: Potent Glycogen Synthase Kinase-3 (GSK-3) Inhibitors with in Vivo Activity in Model of Mood Disorders

Guido Furlotti, Maria Alessandra Alisi, Nicola Cazzolla, +13

Journal of Medicinal Chemistry

Novel TreatmentsPharmacotherapySystem PharmacologyChemical BiologyPharmaceutical Chemistry +17