Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery

Janina Ratajczak, Katarzyna Miękus, Magda Kucia, +4

Leukemia

Embryonic Stem CellDevelopmental BiologyHematopoietic ProgenitorsMedicineStem Cell Mobilization +9

Haploinsufficiency of CBFA2 causes familial thrombocytopenia with propensity to develop acute myelogenous leukaemia

Woo‐Joo Song, Melanie G. Sullivan, Robert D. Legare, +21

Nature Genetics

Hematological MalignancyThrombosisAcute Myelogenous LeukaemiaAutoimmune DiseaseMixed-phenotype Acute Leukemia +9

Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer

Anna Janowska‐Wieczorek, Marcin Wysoczynski, Jacek Kijowski, +3

International Journal of Cancer

Tumor BiologyAngiogenesisOncologyMedicineCell Lines +12

A population of very small embryonic-like (VSEL) CXCR4+SSEA-1+Oct-4+ stem cells identified in adult bone marrow

Magda Kucia, Ryan Reca, Ferrell R. Campbell, +4

Leukemia

Cxcr4+ssea-1+oct-4+ Stem CellsEmbryonic Stem CellAdult Bone MarrowDevelopmental BiologyMedicine +9

Migration of Bone Marrow and Cord Blood Mesenchymal Stem Cells In Vitro Is Regulated by Stromal‐Derived Factor‐1‐CXCR4 and Hepatocyte Growth Factor‐c‐met Axes and Involves Matrix Metalloproteinases

Bo‐Ra Son, Leah A. Marquez‐Curtis, Magda Kucia, +5

Stem Cells

Adult Stem CellImmunologyBiomedical EngineeringStem Cell MigrationStem Cell Biology +21

Numerous growth factors, cytokines, and chemokines are secreted by human CD34+ cells, myeloblasts, erythroblasts, and megakaryoblasts and regulate normal hematopoiesis in an autocrine/paracrine manner

Marcin Majka, Anna Janowska‐Wieczorek, Janina Ratajczak, +6

Blood

Platelet-derived microparticles bind to hematopoietic stem/progenitor cells and enhance their engraftment

Anna Janowska‐Wieczorek, Marcin Majka, Jacek Kijowski, +7

Blood

Cells Expressing Early Cardiac Markers Reside in the Bone Marrow and Are Mobilized Into the Peripheral Blood After Myocardial Infarction

Magda Kucia, Buddhadeb Dawn, Greg Hunt, +8

Circulation Research

Adult Stem CellImmunologyCardiac Progenitor CellsBlood CellPeripheral Blood +18

Platelet- and megakaryocyte-derived microparticles transfer CXCR4 receptor to CXCR4-null cells and make them susceptible to infection by X4-HIV

Tomasz Rozmysłowicz, Marcin Majka, Jacek Kijowski, +6

AIDS

Stem cell plasticity revisited: CXCR4-positive cells expressing mRNA for early muscle, liver and neural cells ‘hide out’ in the bone marrow

Mariusz Z. Ratajczak, Magda Kucia, Ryan Reca, +3

Leukemia

Early MuscleDevelopmental BiologyStem Cell PlasticityMedicineAdult Stem Cell +6