KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer

Fotios Loupakis, Annamaria Ruzzo, Chiara Cremolini, +17

British Journal of Cancer

PTEN Expression and KRAS Mutations on Primary Tumors and Metastases in the Prediction of Benefit From Cetuximab Plus Irinotecan for Patients With Metastatic Colorectal Cancer

Fotios Loupakis, Luca Emanuele Pollina, I. Stasi, +17

Journal of Clinical Oncology

Pharmacogenetic Profiling in Patients With Advanced Colorectal Cancer Treated With First-Line FOLFOX-4 Chemotherapy

Annamaria Ruzzo, Francesco Graziano, Fotios Loupakis, +17

Journal of Clinical Oncology

High Concordance of <i>KRAS</i> Status Between Primary Colorectal Tumors and Related Metastatic Sites: Implications for Clinical Practice

Daniele Santini, Fotios Loupakis, Bruno Vincenzi, +17

The Oncologist

Genetic Activation of the <i>MET</i> Pathway and Prognosis of Patients With High-Risk, Radically Resected Gastric Cancer

Francesco Graziano, Nadia Galluccio, Paola Lorenzini, +14

Journal of Clinical Oncology

Pharmacogenetic Profiling for Cetuximab Plus Irinotecan Therapy in Patients With Refractory Advanced Colorectal Cancer

Francesco Graziano, Annamaria Ruzzo, Fotios Loupakis, +17

Journal of Clinical Oncology

Pharmacogenetic Profiling and Clinical Outcome of Patients With Advanced Gastric Cancer Treated With Palliative Chemotherapy

Annamaria Ruzzo, Francesco Graziano, Kazuyuki Kawakami, +16

Journal of Clinical Oncology

Genetic modulation of the Let-7 microRNA binding to KRAS 3′-untranslated region and survival of metastatic colorectal cancer patients treated with salvage cetuximab–irinotecan

Francesco Graziano, Emanuele Canestrari, Fotios Loupakis, +14

The Pharmacogenomics Journal

Kras 3′-Untranslated RegionOncologyEpigenetic RegulationMedicineColorectal Cancer +9

Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy

Annamaria Ruzzo, Francesco Graziano, Fotios Loupakis, +19

The Pharmacogenomics Journal

OncologyChemoprevention StrategyMedicinePathologyColorectal Cancer +7

High Let-7a MicroRNA Levels in <i>KRAS</i>-Mutated Colorectal Carcinomas May Rescue Anti-EGFR Therapy Effects in Patients with Chemotherapy-Refractory Metastatic Disease

Annamaria Ruzzo, Francesco Graziano, Bruno Vincenzi, +12

The Oncologist

Kras MrnaPathologyCancer BiologyTumor BiologyOncology +14