Daniel G. Mackensen

Physiologically based pharmacokinetic model for specific and nonspecific monoclonal antibodies and fragments in normal tissues and human tumor xenografts in nude mice.

Laurence T. Baxter, Hui Zhu, Daniel G. Mackensen et al. · PubMed · 1994 · 282 citations

Immunocytochemical Technique, Immunology, Binding Affinity +19

Biodistribution of monoclonal antibodies: scale-up from mouse to human using a physiologically based pharmacokinetic model.

Laurence T. Baxter, Hui Zhu, Daniel G. Mackensen et al. · PubMed · 1995 · 179 citations

Immunocytochemical Technique, Engineering, Immunology +20

Site-specific prodrug activation by antibody-beta-lactamase conjugates: regression and long-term growth inhibition of human colon carcinoma xenograft models.

Damon L. Meyer, Louis N. Jungheim, Kevin L. Law et al. · PubMed · 1993 · 62 citations

Engineering, Immunology, Tumor Biology +19

Reversal of Vinca alkaloid resistance by anti-P-glycoprotein monoclonal antibody HYB-241 in a human tumor xenograft.

L Rittmann-Grauer, M A Yong, V Sanders et al. · PubMed · 1992 · 48 citations

Antibiotic Adjuvant, Immunology, Pathology +18