Natasha Rozenkrants

Oxysterols are agonist ligands of RORγt and drive Th17 cell differentiation

Pejman Soroosh, Jiejun Wu, Xiaohua Xue et al. · Proceedings of the National Academy of Sciences · 2014 · 248 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Pharmacologic modulation of RORγt translates to efficacy in preclinical and translational models of psoriasis and inflammatory arthritis

Xiaohua Xue, Pejman Soroosh, Aimee De Leon-Tabaldo et al. · Scientific Reports · 2016 · 75 citations · Full text

Medicine, Immunology, Pathology +17

Discovery of Inducible Nitric Oxide Synthase (iNOS) Inhibitor Development Candidate KD7332, Part 1: Identification of a Novel, Potent, and Selective Series of Quinolinone iNOS Dimerization Inhibitors that are Orally Active in Rodent Pain Models

Céline Bonnefous, Joseph E. Payne, Jeffrey Roppe et al. · Journal of Medicinal Chemistry · 2009 · 69 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +13

A new α‐helical extension promotes RNA binding by the dsRBD of Rnt1p RNAse III

Nicolas Leulliot, Sophie Quevillon‐Chéruel, Marc Graille et al. · The EMBO Journal · 2004 · 59 citations · Full text

Life Sciences, Molecular Biology, Rna Biology +9

Discovery of Dual Inducible/Neuronal Nitric Oxide Synthase (iNOS/nNOS) Inhibitor Development Candidate 4-((2-Cyclobutyl-1<i>H</i>-imidazo[4,5-<i>b</i>]pyrazin-1-yl)methyl)-7,8-difluoroquinolin-2(1<i>H</i>)-one (KD7332) Part 2: Identification of a Novel, Potent, and Selective Series of Benzimidazole-Quinolinone iNOS/nNOS Dimerization Inhibitors That Are Orally Active in Pain Models

Joseph E. Payne, Céline Bonnefous, Kent T. Symons et al. · Journal of Medicinal Chemistry · 2010 · 58 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +12