Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

Marcus D. Tuttle, Gemma Comellas, Andrew J. Nieuwkoop, +12

Nature Structural & Molecular Biology

Neurodegenerative DiseasesSolid-state Nmr StructureMolecular BiologyStructural BiologyProtein Misfolding +5

Amphotericin forms an extramembranous and fungicidal sterol sponge

Thomas M. Anderson, Mary C. Clay, Alexander G. Cioffi, +12

Nature Chemical Biology

BiosynthesisAntifungal AgentMedicineMedicinal FungiMicrobiology +2

Structured Regions of α-Synuclein Fibrils Include the Early-Onset Parkinson's Disease Mutation Sites

Gemma Comellas, Luisel Lemkau, Andrew J. Nieuwkoop, +7

Journal of Molecular Biology

Neurodegenerative DiseasesProtein FoldingMolecular Biologyα-Synuclein Fibrils IncludeDegenerative Pathology +6

Structural Intermediates during α-Synuclein Fibrillogenesis on Phospholipid Vesicles

Gemma Comellas, Luisel Lemkau, Donghua H. Zhou, +2

Journal of the American Chemical Society

Proteinlipid InteractionProtein AssemblyProtein Phase SeparationAnalytical UltracentrifugationPhospholipid Vesicles +15

Solid-state NMR analysis of membrane proteins and protein aggregates by proton detected spectroscopy

Donghua H. Zhou, Andrew J. Nieuwkoop, Gemma Comellas, +6

Journal of Biomolecular NMR

BiochemistryMagnetic Resonance SpectroscopyProtein FoldingElectron Paramagnetic ResonanceSolid-state Nmr Analysis +7

Mutant Protein A30P α-Synuclein Adopts Wild-type Fibril Structure, Despite Slower Fibrillation Kinetics

Luisel Lemkau, Gemma Comellas, Kathryn D. Kloepper, +3

Journal of Biological Chemistry

NeurogenomicsSecondary StructureMolecular BiologyAnalytical UltracentrifugationSynaptic Signaling +19

Straightforward, effective calibration of SPINAL-64 decoupling results in the enhancement of sensitivity and resolution of biomolecular solid-state NMR

Gemma Comellas, Jakob J. Lopez, Andrew J. Nieuwkoop, +2

Journal of Magnetic Resonance

EngineeringMagnetic Resonance SpectroscopyBiomolecular AnalysisBiomedical ImagingMagnetic Resonance +8

Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K

Luisel Lemkau, Gemma Comellas, Shin W. Lee, +4

PLoS ONE

Wt As FibrilsNeurogenomicsMolecular BiologyNeurochemical BiomarkersSynaptic Signaling +21

High resolution 13C-detected solid-state NMR spectroscopy of a deuterated protein

Ming Tang, Gemma Comellas, Leonard J. Mueller, +1

Journal of Biomolecular NMR

Deuterated ProteinBiochemistryMagnetic Resonance SpectroscopyNatural SciencesMagnetic Resonance +5

Experimental Protein Structure Verification by Scoring with a Single, Unassigned NMR Spectrum

Joseph M. Courtney, Qing Ye, Anna E. Nesbitt, +9

Structure

BiochemistryBiomolecular Structure PredictionProtein FoldingMedicineNatural Sciences +9