A systematic approach to identify novel cancer drug targets using machine learning, inhibitor design and high-throughput screening

Jouhyun Jeon, Satra Nim, Joan Teyra, +5

Genome Medicine

Large-scale interaction profiling of PDZ domains through proteomic peptide-phage display using human and viral phage peptidomes

Ylva Ivarsson, Roland Arnold, M. A. McLaughlin, +10

Proceedings of the National Academy of Sciences

Method to generate highly stable D-amino acid analogs of bioactive helical peptides using a mirror image of the entire PDB

Michael Garton, Satra Nim, Tracy A. Stone, +3

Proceedings of the National Academy of Sciences

Discovery of short linear motif‐mediated interactions through phage display of intrinsically disordered regions of the human proteome

Norman E. Davey, Moon‐Hyeong Seo, Vikash Kumar Yadav, +8

FEBS Journal

Short LinearProtein AssemblyMolecular BiologyPeptide ScienceAnalytical Ultracentrifugation +20

PepNN: a deep attention model for the identification of peptide binding sites

Osama Abdin, Satra Nim, Han Wen, +1

Communications Biology

A universal deep-learning model for zinc finger design enables transcription factor reprogramming

David M. Ichikawa, Osama Abdin, Nader Alerasool, +18

Nature Biotechnology

Subcellular localization of coagulation factor II receptor-like 1 in neurons governs angiogenesis

Jean Sébastien Joyal, Satra Nim, Tang Zhu, +23

Nature Medicine

Signal TransductionAngiogenesisDevelopmental BiologyEndothelial DysfunctionSubcellular Localization +7

Computational Design of Potent D-Peptide Inhibitors of SARS-CoV-2

Pedro A. Valiente, Han Wen, Satra Nim, +9

Journal of Medicinal Chemistry

Generation and Validation of Intracellular Ubiquitin Variant Inhibitors for USP7 and USP10

Wei Zhang, Maria A. Sartori, Taras Makhnevych, +13

Journal of Molecular Biology

MedicineProteomicsPharmacologyCell BiologyDrug Discovery

Pooled screening for antiproliferative inhibitors of protein-protein interactions

Satra Nim, Jouhyun Jeon, Carles Corbi‐Verge, +5

Nature Chemical Biology

Drug TargetBiochemistryMedicinePharmacologyRational Drug Design +3