SGLT2 inhibition eliminates senescent cells and alleviates pathological aging

Goro Katsuumi, Ippei Shimizu, Masayoshi Suda, +10

Nature Aging

Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle

Tomoyasu Kadoguchi, Shintaro Kinugawa, Shingo Takada, +11

Experimental Physiology

HypertensionHeart FailureMitochondrial DysfunctionCardiovascular FunctionOxidative Stress +14

Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of glucagon-like peptide-1 receptor signalling

Shingo Takada, Yoshihiro Masaki, Shintaro Kinugawa, +13

Cardiovascular Research

AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress

Mikito Nishikawa, Naoki Ishimori, Shingo Takada, +8

Nephrology Dialysis Transplantation

Empagliflozin restores lowered exercise endurance capacity via the activation of skeletal muscle fatty acid oxidation in a murine model of heart failure

Hideo Nambu, Shingo Takada, Arata Fukushima, +12

European Journal of Pharmacology

Heart FailureMetabolic RemodelingCardiovascular FunctionOxidative StressMetabolic Syndrome +18

Serine biosynthesis as a novel therapeutic target for dilated cardiomyopathy

Isaac Perea‐Gil, Timon Seeger, Arne A.N. Bruyneel, +19

European Heart Journal

Serum myostatin levels are independently associated with skeletal muscle wasting in patients with heart failure

Takaaki Furihata, Shintaro Kinugawa, Arata Fukushima, +8

International Journal of Cardiology

Metabolic SyndromeCardiomyopathyHeart FailureCardiac MuscleCardiovascular Disease +9

Protein acetylation in skeletal muscle mitochondria is involved in impaired fatty acid oxidation and exercise intolerance in heart failure

Masaya Tsuda, Arata Fukushima, Junichi Matsumoto, +9

Journal of Cachexia Sarcopenia and Muscle

Heart FailureMitochondrial BiologyMetabolic RemodelingOxidative StressMetabolic Syndrome +20

Succinyl-CoA-based energy metabolism dysfunction in chronic heart failure

Shingo Takada, Satoshi Maekawa, Takaaki Furihata, +14

Proceedings of the National Academy of Sciences

Heart FailureMitochondrial DysfunctionLipid PeroxidationMitochondrial BiologyMetabolic Remodeling +22

Linoleic acid improves assembly of the CII subunit and CIII2/CIV complex of the mitochondrial oxidative phosphorylation system in heart failure

Satoshi Maekawa, Shingo Takada, Hideo Nambu, +7

Cell Communication and Signaling