TREM2 Modulation Remodels the Tumor Myeloid Landscape Enhancing Anti-PD-1 Immunotherapy

Martina Molgora, Ekaterina Esaulova, William Vermi, +17

Cell

Cancer ImmunosurveillanceMedicineT-regulatory CellImmunologyTumor Immunity +8

PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

Eduardo Bonavita, Stefania Gentile, Marcello Rubino, +21

Cell

InflammationCytokineComplement SystemImmunologyPathology +5

Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload–Driven Heart Failure Reveals Extent of Immune Activation

Elisa Martini, Paolo Kunderfranco, Clelia Peano, +20

Circulation

Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer

Eleonora Timperi, Paul Gueguen, Martina Molgora, +17

Cancer Research

Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors

Andrea Ponzetta, Roberta Carriero, Silvia Carnevale, +20

Cell

IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity

Martina Molgora, Eduardo Bonavita, Andrea Ponzetta, +12

Nature

MedicineAnti-viral ActivityImmunologyImmunologic MechanismImmune Checkpoint Inhibitor +6

TREM2 macrophages drive NK cell paucity and dysfunction in lung cancer

Matthew D. Park, Ivan Reyes-Torres, Jessica LeBérichel, +30

Nature Immunology

Lung InflammationMedicineImmunologyCell DeathNk Cell Paucity +6

The macrophage tetraspan MS4A4A enhances dectin-1-dependent NK cell–mediated resistance to metastasis

Irene Mattiola, Federica Tomay, Maria De Pizzol, +21

Nature Immunology

Dectin-1-dependent NkCancer ImmunosurveillanceMedicineImmunologyTumor Immunity +6

Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways

Irene Mattiola, Matthieu Pesant, Paolo Tentorio, +5

The Journal of Immunology

A Cre-deleter specific for embryo-derived brain macrophages reveals distinct features of microglia and border macrophages

Simone Brioschi, Julia A. Belk, Vincent Peng, +16

Immunity

EpendymaMedicineBorder MacrophagesBrain-immune InteractionNeuroscience +5