Christina Jacob

Hypoxic activation of glucose-6-phosphate dehydrogenase controls the expression of genes involved in the pathogenesis of pulmonary hypertension through the regulation of DNA methylation

Sachindra Raj Joshi, A. Kitagawa, Christina Jacob et al. · American Journal of Physiology-Lung Cellular and Molecular Physiology · 2020 · 59 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

G6PD activity contributes to the regulation of histone acetylation and gene expression in smooth muscle cells and to the pathogenesis of vascular diseases

Vidhi Dhagia, A. Kitagawa, Christina Jacob et al. · American Journal of Physiology-Heart and Circulatory Physiology · 2021 · 32 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

CRISPR-Mediated Single Nucleotide Polymorphism Modeling in Rats Reveals Insight Into Reduced Cardiovascular Risk Associated With Mediterranean <i>G6PD</i> Variant

A. Kitagawa, Igor V. Kizub, Christina Jacob et al. · Hypertension · 2020 · 27 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Inhibition of Glucose-6-Phosphate Dehydrogenase Activity Attenuates Right Ventricle Pressure and Hypertrophy Elicited by VEGFR Inhibitor + Hypoxia

A. Kitagawa, Christina Jacob, Allan M. Jordan et al. · Journal of Pharmacology and Experimental Therapeutics · 2021 · 21 citations · Full text

Medicine, Oncology, Pharmacology +17

Mediterranean G6PD variant mitigates expression of DNA methyltransferases and right heart pressure in experimental model of pulmonary hypertension

Christina Jacob, A. Kitagawa, Christina Signoretti et al. · Journal of Biological Chemistry · 2022 · 11 citations · Full text

Life Sciences, Genetics, Molecular Biology +13