New Paradigm for Lymphocyte Granule-mediated Cytotoxicity

Christopher J. Froelich, Kim Orth, Jane M. Turbov, +7

Journal of Biological Chemistry

Extracellular Granzymes A and B in Humans: Detection of Native Species During CTL Responses In Vitro and In Vivo

Elisabeth H. A. Spaeny-Dekking, William Hanna, Angela M. Wolbink, +7

The Journal of Immunology

Human granzyme B degrades aggrecan proteoglycan in matrix synthesized by chondrocytes.

Christopher J. Froelich, Xiang Zhang, Jane M. Turbov, +3

The Journal of Immunology

ImmunologyPolysaccharideGranule-associated Serine ProteasesCartilage DegradationCellular Physiology +22

Extracellular Activities of Human Granzymes

Laurie Sower, Gary R. Klimpel, William Hanna, +1

Cellular Immunology

Extracellular ActivitiesCellular EnzymologyBiochemistryGranulocyteNatural Sciences +6

Cytotoxic T-cell-derived granzyme B activates the apoptotic protease ICE-LAP3

Arul M. Chinnaiyan, William Hanna, Kim Orth, +4

Current Biology

MedicineApoptotic Protease Ice-lap3ApoptosisImmunologyAutophagy +7

Granzyme B/Perforin-Mediated Apoptosis of Jurkat Cells Results in Cleavage of Poly(ADP-ribose) Polymerase to the 89-kDa Apoptotic Fragment and Less Abundant 64-kDa Fragment

Christopher J. Froelich, William Hanna, Guy G. Poirier, +6

Biochemical and Biophysical Research Communications

ApoptosisImmunologyCell DeathGranzyme B/perforin-mediated ApoptosisJurkat Cells Results +3

Rapid Purification of Cationic Granule Proteases: Application to Human Granzymes

William Hanna, X.L. Zhang, Jane M. Turbov, +3

Protein Expression and Purification

BiochemistryNatural SciencesRapid PurificationBioanalysisBiotechnology +4

Human granzyme B is essential for DNA fragmentation of susceptible target cells

Bin Su, Markian R. Bochan, William Hanna, +2

European Journal of Immunology

Dominant chymotrypsin-like esterase activity in human lymphocyte granules is mediated by the serine carboxypeptidase called cathepsin A-like protective protein.

William Hanna, Jane M. Turbov, Herbert L. Jackman, +2

The Journal of Immunology

Human Perforin: Rapid Enrichment by Immobilized Metal Affinity Chromatography (IMAC) for Whole Cell Cytotoxicity Assays

Christopher J. Froelich, Jane M. Turbov, William Hanna

Biochemical and Biophysical Research Communications

BiochemistryMetalloproteinBioanalysisImmunologyHuman Perforin +5