Jan Walther Perthold

ACE2 is the critical in vivo receptor for SARS-CoV-2 in a novel COVID-19 mouse model with TNF- and IFNγ-driven immunopathology

Riem Gawish, Philipp Starkl, Lisabeth Pimenov et al. · eLife · 2022 · 66 citations · Full text

Clinical Immunology, Lung Inflammation, Viral Pathogenesis +20

Structure-guided glyco-engineering of ACE2 for improved potency as soluble SARS-CoV-2 decoy receptor

Tümay Capraz, Nikolaus F. Kienzl, Elisabeth Laurent et al. · eLife · 2021 · 41 citations · Full text

Ace2 N-glycans, Glycobiology, Immunology +17

Simulation of Reversible Protein–Protein Binding and Calculation of Binding Free Energies Using Perturbed Distance Restraints

Jan Walther Perthold, Chris Oostenbrink · Journal of Chemical Theory and Computation · 2017 · 40 citations · Full text

Accelerated Enveloping Distribution Sampling: Enabling Sampling of Multiple End States while Preserving Local Energy Minima

Jan Walther Perthold, Chris Oostenbrink · The Journal of Physical Chemistry B · 2018 · 33 citations · Full text

Eds Hamiltonian Parameters, Engineering, Single Molecular Dynamics +21

Toward Automated Free Energy Calculation with Accelerated Enveloping Distribution Sampling (A-EDS)

Jan Walther Perthold, Dražen Petrov, Chris Oostenbrink · Journal of Chemical Information and Modeling · 2020 · 29 citations · Full text

Engineering, Energy Efficiency, Energy Conversion +19