Sean C. Gay

Crystal Structure of a Cytochrome P450 2B6 Genetic Variant in Complex with the Inhibitor 4-(4-Chlorophenyl)imidazole at 2.0-Å Resolution

Sean C. Gay, Manish B. Shah, Jyothi C. Talakad et al. · Molecular Pharmacology · 2010 · 91 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17

Crystal Structures of Cytochrome P450 2B4 in Complex with the Inhibitor 1-Biphenyl-4-methyl-1<i>H</i>-imidazole: Ligand-Induced Structural Response through α-Helical Repositioning^,

Sean C. Gay, Ling Sun, Keiko Maekawa et al. · Biochemistry · 2009 · 46 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +17

Structures of Cytochrome P450 2B4 Complexed with the Antiplatelet Drugs Ticlopidine and Clopidogrel,

Sean C. Gay, Arthur G. Roberts, Keiko Maekawa et al. · Biochemistry · 2010 · 40 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3-Oxo-3,4-dihydro-2<i>H</i>-benzo[<i>b</i>][1,4]oxazin-6-yl Moiety

Shuhei Ikeda, Hideyuki Sugiyama, Hidekazu Tokuhara et al. · Journal of Medicinal Chemistry · 2021 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +16

Structural Analysis of Mammalian Cytochrome P450 2B4 Covalently Bound to the Mechanism-Based Inactivator<i>tert</i>-Butylphenylacetylene: Insight into Partial Enzymatic Activity

Sean C. Gay, Haoming Zhang, P. Ross Wilderman et al. · Biochemistry · 2011 · 37 citations

Life Sciences, Biochemistry, Molecular Biology +17