Didier Bénard

SAR and X-ray. A New Approach Combining Fragment-Based Screening and Rational Drug Design:  Application to the Discovery of Nanomolar Inhibitors of Src SH2

Dominique Lesuisse, Gudrun Lange, Pierre Deprez et al. · Journal of Medicinal Chemistry · 2002 · 90 citations · Full text

Requirements for Specific Binding of Low Affinity Inhibitor Fragments to the SH2 Domain of^pp60Src Are Identical to Those for High Affinity Binding of Full Length Inhibitors

Gudrun Lange, Dominique Lesuisse, Pierre Deprez et al. · Journal of Medicinal Chemistry · 2003 · 62 citations · Full text

Drug Target, Engineering, Phospho-tyrosine Pocket +17

A Mild Method for Formylating Amino Esters Without Using any Formylating Agent

Thierry Giard, Didier Bénard, Jean‐Christophe Plaquevent · Synthesis · 1998 · 15 citations

Formylating Agent, Formylating Amino Esters, Biochemistry +8

Synthesis of 1‐amino‐[1,2,3]oxadiazolo[4,3‐α]phthalazin‐4‐ium chloride and substituted dihydro derivatives. New annelated sydnonimines

Jean-Marie Ruxer, Jacques Mauger, Didier Bénard et al. · Journal of Heterocyclic Chemistry · 1995 · 14 citations

Derivatives, Engineering, Natural Sciences +13

Principles Governing the Binding of a Class of Non-Peptidic Inhibitors to the SH2 Domain of src Studied by X-ray Analysis

Gudrun Lange, Dominique Lesuisse, Pierre Deprez et al. · Journal of Medicinal Chemistry · 2002 · 13 citations · Full text

Protein Assembly, Molecular Biology, Water Molecules +17