Depletion of GGA3 Stabilizes BACE and Enhances β-Secretase Activity

Giuseppina Tesco, Young Ho Koh, Eugene L. Kang, +9

Neuron

Protein SecretionSignal TransductionBiochemistryNatural SciencesGga3 Stabilizes Bace +5

Presenilin-Mediated Modulation of Capacitative Calcium Entry

Andrew S. Yoo, Isaac T Cheng, Sungkwon Chung, +12

Neuron

Molecular PhysiologySignal TransductionNeurophysiologyMedicinePhysiology +6

Molecular mechanisms of cognitive dysfunction following traumatic brain injury

Kendall R. Walker, Giuseppina Tesco

Frontiers in Aging Neuroscience

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

Minji Kim, Jaehong Suh, Donna Romano, +9

Human Molecular Genetics

Traumatic Brain Injury Increases Cortical Glutamate Network Activity by Compromising GABAergic Control

David Cantu, Kendall R. Walker, Amaro Taylor‐Weiner, +3

Cerebral Cortex

BACE Is Degraded via the Lysosomal Pathway

Young Ho Koh, Christine A. F. Von Arnim, Bradley T. Hyman, +2

Journal of Biological Chemistry

Protein SecretionMolecular BiologyMolecular GeneticsAmyloid Precursor ProteinAlzheimer's Disease +14

Inhibition of Microglial Activation Protects Hippocampal Neurogenesis and Improves Cognitive Deficits in a Transgenic Mouse Model for Alzheimer’s Disease

Barbara Biscaro, Olle Lindvall, Giuseppina Tesco, +2

Neurodegenerative Diseases

Protein Aggregates and Novel Presenilin Gene Variants in Idiopathic Dilated Cardiomyopathy

Davide Gianni, Airong Li, Giuseppina Tesco, +13

Circulation

Ubiquitin Regulates GGA3-mediated Degradation of BACE1

Eugene L. Kang, Andrew N. Cameron, Fabrizio Piazza, +2

Journal of Biological Chemistry

Cell DeathGga3 ResultsSignaling PathwayCell RegulationAutophagy +17

Ubiquilin 1 Modulates Amyloid Precursor Protein Trafficking and Aβ Secretion

Mikko Hiltunen, Alice Lu, Anne V. Thomas, +11

Journal of Biological Chemistry

Protein SecretionMolecular BiologyAmyloid Precursor ProteinAlzheimer's DiseaseProtein Folding +14