21:I[432972,["/_next/static/chunks/bb923814e1f4d2e9.js","/_next/static/chunks/dd3ee9f5b7716ca6.js","/_next/static/chunks/4204a0ae82542ca8.js","/_next/static/chunks/1270dead247da766.js","/_next/static/chunks/6e1aa89a642f40be.js","/_next/static/chunks/2d7aa753e81324a8.js","/_next/static/chunks/8ffd0b71567920d8.js","/_next/static/chunks/67ea6dfd21f16c5f.js","/_next/static/chunks/24eb4379f68013fd.js","/_next/static/chunks/b8cd775ffdf935bd.js","/_next/static/chunks/983103cd9eb7b428.js","/_next/static/chunks/263f2cdcb9aa2341.js","/_next/static/chunks/294b9525248c8e5f.js"],"default"] 22:T51d,Tumor hypoxia and systemic toxicity seriously affect the efficacy of photodynamic therapy (PDT) and are considered as the "Achilles' heel" of PDT. Herein, to combat such limitations, an intelligent orthogonal emissions LDNP@SiO₂ -CaO₂ and folic acid-polyethylene glycol-Ce6 nanodrug is rationally designed and fabricated not only for relieving the hypoxic tumor microenvironment (TME) to enhance PDT efficacy, but also for determining the optimal triggering time through second near-infrared (NIR-II) fluorescence imaging. The designed nanodrug continuously releases a large amount of O₂ , H₂ O₂ , and Ca²⁺ ions when exposed to the acidic TME. Meanwhile, under downshifting NIR-II bioimaging guidance, chlorine e6 (Ce6) consumes oxygen to produce ¹ O₂ upon excitation of upconversion photon. Moreover, cytotoxic reactive oxygen species (ROS) and calcium overload can induce mitochondria injury and thus enhance the oxidative stress in tumor cells. As a result, the NIR-II bioimaging guided TME-responsive oxygen self-sufficient PDT nanosystem presents enhanced anti-tumor efficacy without obvious systemic toxicity. Thus, the fabricated nanodrug offers great potential for designing an accurate cancer theranostic system.23:T406,Abstract Digital fringe projection (DFP) is widely applied in three-dimensional (3D) shape measurements. However, its performance is severely disturbed while measuring complex surfaces with an extensive range of reflectivity. In this paper, to enhance the underexposed regions and reduce the saturated regions, an automatic and effective method is proposed for the multi-exposure determination of the DFP system. During the whole process, only one unsaturated image must be captured preliminarily, which could establish an adaptive strategy based on the intensity value distribution function. Raw absolute phase maps captured with different exposure times are synthesized at the pixel level for phase retrieval and 3D reconstruction. To evaluate the effectiveness of our method, a high dynamic range method and a global optimal exposure method are introduced for comparison. Verification experiments demonstrate that our method performs better for the 3D reconstruction results of complex surfaces with a large reflectivity range.

#	Concept	H-Index	Publications	Citations
1	Engineering	1	1	16
2	Natural Sciences	1	1	16
3	Geometric Modeling	1	1	16
4	Laser Applications	1	1	16
5	Measurement	1	1	16

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