Inherited STING-activating mutation underlies a familial inflammatory syndrome with lupus-like manifestations

Nadia Jeremiah, Bénédicte Neven, Matteo Gentili, +15

Journal of Clinical Investigation

Innate Immune SystemImmunologyImmune RegulationPathologyImmunologic Mechanism +22

Cancer cells dying from ferroptosis impede dendritic cell-mediated anti-tumor immunity

Bartosz Wiernicki, Sophia Maschalidi, Jonathan J. Pinney, +4

Nature Communications

Targeting SLC7A11 improves efferocytosis by dendritic cells and wound healing in diabetes

Sophia Maschalidi, Parul Mehrotra, Burcu Nur Keçeli, +10

Nature

InflammationSlc7a11 Improves EfferocytosisSignal TransductionCell InteractionDiabetes +9

Critical Role for Asparagine Endopeptidase in Endocytic Toll-like Receptor Signaling in Dendritic Cells

Fernando E. Sepulveda, Sophia Maschalidi, Renaud Colisson, +7

Immunity

InflammationToll-like ReceptorsSignal TransductionAutoimmune DiseaseAsparagine Endopeptidase +11

Therapeutic effect of JAK1/2 blockade on the manifestations of hemophagocytic lymphohistiocytosis in mice

Sophia Maschalidi, Fernando E. Sepulveda, Alexandrine Garrigue, +2

Blood

Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing

Delphyne Descamps, Mathieu Le Gars, Viviane Balloy, +7

Proceedings of the National Academy of Sciences

Oxylipins and metabolites from pyroptotic cells act as promoters of tissue repair

Parul Mehrotra, Sophia Maschalidi, Laura Boeckaerts, +17

Nature

Reductive StressSignal TransductionOxysterolBiochemistryLipid Peroxidation +9

A novel immunoregulatory role for NK-cell cytotoxicity in protection from HLH-like immunopathology in mice

Fernando E. Sepulveda, Sophia Maschalidi, Christian A. J. Vosshenrich, +6

Blood

Asparagine Endopeptidase Controls Anti-Influenza Virus Immune Responses through TLR7 Activation

Sophia Maschalidi, Signe Hässler, Fany Blanc, +7

PLoS Pathogens

STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells

Paula Nunes, Sophia Maschalidi, Carla Lippens, +11

Nature Communications