Targeting cardiac fibrosis with engineered T cells

Haig Aghajanian, Tōru Kimura, Joel G. Rurik, +22

Nature

Regenerative MedicineCell TherapyFibrosisCardiac ReprogrammingEngineered T Cells +6

Plasticity of Hopx+ type I alveolar cells to regenerate type II cells in the lung

Rajan Jain, Christina E. Barkauskas, Norifumi Takeda, +11

Nature Communications

β-Hydroxybutyrate suppresses colorectal cancer

Oxana Dmitrieva-Posocco, Andrea C. Wong, Patrick Lundgren, +33

Nature

Tumor BiologyChemoprevention StrategyGastrointestinal OncologyMedicinePharmacology +3

A Common Embryonic Origin of Stem Cells Drives Developmental and Adult Neurogenesis

Daniel A. Berg, Yijing Su, Dennisse Jimenez-Cyrus, +13

Cell

Adult NeurogenesisNeuroregenerationDevelopmental BiologyMedicineCommon Embryonic Origin +9

Bromodomains Mediate an Acetyl-Histone Encoded Antisilencing Function at Heterochromatin Boundaries

Andreas G. Ladurner, Carla Inouye, Rajan Jain, +1

Molecular Cell

Histone ModificationsChromatinChromatin StructureChromatin RemodelingNatural Sciences +9

Genome-Nuclear Lamina Interactions Regulate Cardiac Stem Cell Lineage Restriction

Andrey Poleshko, Parisha P. Shah, Mudit Gupta, +16

Cell

ChromatinCardiomyopathyCardiac MuscleDevelopmental BiologyCardiac Reprogramming +7

In utero CRISPR-mediated therapeutic editing of metabolic genes

Avery C. Rossidis, John D. Stratigis, Alexandra C. Chadwick, +14

Nature Medicine

EngineeringGenome SurgeryMedicineGeneticsSynthetic Biology +6

A transcriptional switch governs fibroblast activation in heart disease

Michael Alexanian, Pawel F. Przytycki, Rudi Micheletti, +22

Nature

Transcriptional RegulationFibrosisCardiac ReprogrammingCardiomyopathyCardiac Progenitor Cells +6

Murine Jagged1/Notch signaling in the second heart field orchestrates Fgf8 expression and tissue-tissue interactions during outflow tract development

Frances A. High, Rajan Jain, Jason Z. Stoller, +6

Journal of Clinical Investigation

Cardiac Progenitor CellsOrgan DevelopmentCongenital Heart AnomalyCellular PhysiologyAngiogenesis +17

Cardiac neural crest orchestrates remodeling and functional maturation of mouse semilunar valves

Rajan Jain, Kurt A. Engleka, Stacey Rentschler, +4

Journal of Clinical Investigation

Cardiac MuscleHeart FailureCardiac Progenitor CellsCardiovascular FunctionCongenital Heart Anomaly +19