Steve R. Lee

NKTR-214, an Engineered Cytokine with Biased IL2 Receptor Binding, Increased Tumor Exposure, and Marked Efficacy in Mouse Tumor Models

Deborah H. Charych, Ute Hoch, John L. Langowski et al. · Clinical Cancer Research · 2016 · 392 citations

Life Sciences, Immunology, Oncology +17

A Fully Human, Allosteric Monoclonal Antibody That Activates the Insulin Receptor and Improves Glycemic Control

Vinay Bhaskar, Ira D. Goldfine, Daniel Bedinger et al. · Diabetes · 2012 · 78 citations · Full text

Medicine, Endocrinology, Pharmacology +16

Kinetic Approach to Pathway Attenuation Using XOMA 052, a Regulatory Therapeutic Antibody That Modulates Interleukin-1β Activity

Marina K. Roell, Hassan Issafras, Robert J. Bauer et al. · Journal of Biological Chemistry · 2010 · 42 citations · Full text

Life Sciences, Immunology, Pharmacology +17

Inhibition of insulin receptor function by a human, allosteric monoclonal antibody

John Corbin, Vinay Bhaskar, Ira D. Goldfine et al. · mAbs · 2013 · 28 citations · Full text

Medicine, Endocrinology, Pharmacology +17

Improved Glucose Metabolism In Vitro and In Vivo by an Allosteric Monoclonal Antibody That Increases Insulin Receptor Binding Affinity

John Corbin, Vinay Bhaskar, Ira D. Goldfine et al. · PLoS ONE · 2014 · 21 citations · Full text

Life Sciences, Biochemistry, Endocrinology +17